ChemicalBook > Product Catalog >Organic Chemistry >Nitrogen Compounds >(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Suppliers list
Company Name: Qingdao Yonghefeng Economic and Trade Co., Ltd.
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Products Intro: Product Name:tert-butyl(R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
CAS:1022150-11-3
Purity:98% Package:5KG;1KG 10kg 25kg
Company Name: Henan Fengda Chemical Co., Ltd
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Products Intro: Product Name:(R)-3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid
CAS:1022150-11-3
Purity:99% Package:1KG;25kg;200kg;1000kg Jessica Remarks:g-kg-tons,free sample is available.Bottle/drum/IBC.Advantage products,new batches,regular stock, ready for shipment.
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Products Intro: Product Name:Ibrutinib Intermediates
CAS:1022150-11-3
Purity:98% Package:1KG;100USD
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Products Intro: Product Name:(R)-tert-Butyl 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
CAS:1022150-11-3
Purity:98% Package:5kg 10kg 25kg per barrel
Company Name: Shanghai Yingrui Biopharma Co.,Ltd
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Products Intro: Product Name:(R)-3-[4-Amino-3-(4-phenoxy-phenyl)- pyrazolo[3,4-d]pyrimidin-1-yl]- piperidine-1-carboxylic acid tert-butyl ester
CAS:1022150-11-3
Purity:0.98 Package:25 kilograms per barrel
(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Basic information
Product Name:(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Synonyms:1-Piperidinecarboxylic acid, 3-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-, 1,1-diMethylethyl ester, (3R)-;(R)-tert-Butyl 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate;(R)-tert-Butyl 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate (N-1);3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester;Ibrutinib Intermediates;(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-ca;(R)-1-(1-Boc-3-piperidinyl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;(R)-3-[4-Amino-3-(4-phenoxy-phenyl)- pyrazolo[3,4-d]pyrimidin-1-yl]- piperidine-1-carboxylic acid tert-butyl ester
CAS:1022150-11-3
MF:C27H30N6O3
MW:486.57
EINECS:
Product Categories:
Mol File:1022150-11-3.mol
(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Structure
(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Chemical Properties
Boiling point 673.9±55.0 °C(Predicted)
density 1.31±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Ethyl Acetate (Slightly)
pka4.09±0.30(Predicted)
form Solid
color White to Off-White
InChIKeyNTSAEGNFPKKRLX-LJQANCHMSA-N
SMILESN1(C(OC(C)(C)C)=O)CCC[C@@H](N2C3C(C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)=C(N)N=CN=3)C1
Safety Information
MSDS Information
(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Usage And Synthesis
UsesN-Boc-Ibrutinib is an impurity of Ibrutinib (I124970), which is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
Synthesis3-(4-phenoxyphenyl) lH-pyrazolo [3,4-d] pyrimidin-4-amine (1.14g, 3.76mmol)was dissolved DMF (30mL) in, and then the reaction solution was added (S)-tert-butyl 3-((methylsulfonyl) oxy) piperidine-1-carboxylate (4.2g, 15.04mmol), cesium carbonate(0.64mL, 8.21 mmol), 4- dimethylaminopyridine pyridine (3.67g, 11.28mmol). Was stirred at 90 ℃, the reaction was completed, distilled under reduced pressure of DMF, and extracted with dichloromethane (150mL × 3), brine (60mL), dried over anhydrous sodium sulfate; the solvent was distilled off under reduced pressure, the crude product was silica gel column Analysis of separation and purification (methylene chloride /methanol (V / V) = 40/1), to give the product (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate (1.28 g, 70 percent).
References[1] Patent: WO2012/158795, 2012, A1. Location in patent: Page/Page column 76
[2] Patent: WO2013/191965, 2013, A1. Location in patent: Page/Page column 156
[3] Patent: WO2014/22569, 2014, A1. Location in patent: Page/Page column 50
[4] Patent: US8673925, 2014, B1. Location in patent: Page/Page column 201
[5] Patent: CN106146511, 2016, A. Location in patent: Paragraph 0150; 0151; 0152
Tag:(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate(1022150-11-3) Related Product Information
Btk inhibitor 1 (R enantioMer hydrochloride) Ibrutinib Impurity 21 (S)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl) (S)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethanone 2-Pyridinamine, 5-methyl-N,N-diphenyl- Ibrutinib Dimer Impurity (S)-Ibrutinib (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one Ibrutinib Impurity 13 Ibrutinib Impurity 4 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine Ibrutinib Impurity 6 Ibrutinib Impurity 12 Ibrutinib Impurity 3 (S)-1-Boc-3-hydroxypiperidine Ibrutinib Impurity 14 (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-chloropropan-1-one