Methyltetrazine-PEG4-Acid manufacturers
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| | Methyltetrazine-PEG4-Acid Basic information |
| Product Name: | Methyltetrazine-PEG4-Acid | | Synonyms: | Methyltetrazine-PEG4-Acid;Methyltetrazine-PEG4-COOH;Methyltetrazine-PEG4-COOH,Methyltetrazine-PEG4-Acid;Propanoic acid, 3-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]-;3-(2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)propanoic acid;1-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)-3,6,9,12-tetraoxapentadecan-15-oic acid;Methyltetrazine-PEG4-Acid (CCT-1073);Methyltetrazine-O-PEG5-acid | | CAS: | 1802907-91-0 | | MF: | C20H28N4O7 | | MW: | 436.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1802907-91-0.mol |  |
| | Methyltetrazine-PEG4-Acid Chemical Properties |
| Boiling point | 647.6±65.0 °C(Predicted) | | density | 1.236±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in Water, DMSO, DMF, DCM | | pka | 4.28±0.10(Predicted) | | form | Solid | | color | Purple to purplish red |
| | Methyltetrazine-PEG4-Acid Usage And Synthesis |
| Description | Methyltetrazine-PEG4-Acid is a stable tetrazines molecule containing a terminal carboxylic acid (CO2H) The terminal acid can react with primary amine groups in the presence of of activators (e.g. EDC, or HATU) to form a stable amide bond. Methyltetrazine enable fast click chemistry with TCO ((trans-cycloctene), methyl group enhances the stability of tetrazine moiety. | | Uses | Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Methyltetrazine-PEG4-Acid Preparation Products And Raw materials |
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