|
|
| | L-DIHYDROOROTIC ACID Basic information |
| | L-DIHYDROOROTIC ACID Chemical Properties |
| Melting point | 254-255 °C (dec.)(lit.) | | Boiling point | 283.16°C (rough estimate) | | density | 1.523 | | refractive index | 1.5090 (estimate) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO (Slightly), Water (Slightly, Heated, Sonicated) | | pka | 2.82±0.20(Predicted) | | form | Powder | | color | White to off-white | | Water Solubility | Soluble in water (partly), and dimethyl formamide. | | InChI | InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1 | | InChIKey | UFIVEPVSAGBUSI-REOHCLBHSA-N | | SMILES | C1(=O)NC(=O)C[C@@H](C(O)=O)N1 | | CAS DataBase Reference | 5988-19-2(CAS DataBase Reference) | | NIST Chemistry Reference | Orotic acid, dihydro-, l-(5988-19-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | L-DIHYDROOROTIC ACID Usage And Synthesis |
| Chemical Properties | White to off-white crystalline powder | | Uses | L-Dihydroorotic acid a metabolite. | | Definition | ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid. | | Biochem/physiol Actions | L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors. | | IC 50 | Microbial Metabolite; Human Endogenous Metabolite |
| | L-DIHYDROOROTIC ACID Preparation Products And Raw materials |
|