| Company Name: |
Shanghai Tauto Biotech Co., Ltd.
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| Tel: |
021-51320588 |
| Email: |
tauto@tautobiotech.com |
| Products Intro: |
Product Name:LEOIDIN(AS)
CAS:105350-54-7
Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:ASB-00012117-005
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Leoidin
CAS:105350-54-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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LEOIDIN(SH) manufacturers
- Leoidin
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- $1470.00
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2026-04-21
- CAS:105350-54-7
- Purity:
- Supply Ability: 10g
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| | LEOIDIN(SH) Basic information |
| Product Name: | LEOIDIN(SH) | | Synonyms: | LEOIDIN(SH);LEOIDIN(AS);11H-Dibenzo[b,e][1,4]dioxepin-7-carboxylic acid, 2,4-dichloro-3,8-dihydroxy-1,6,9-trimethyl-11-oxo-, methyl ester | | CAS: | 105350-54-7 | | MF: | C18H14Cl2O7 | | MW: | 413.208 | | EINECS: | | | Product Categories: | | | Mol File: | 105350-54-7.mol |  |
| | LEOIDIN(SH) Chemical Properties |
| Melting point | 232～233℃ | | storage temp. | Store at -20°C | | solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | A solid |
| | LEOIDIN(SH) Usage And Synthesis |
| Uses | Leoidin is an OATP1B1 and OATP1B3 inhibitor with Ki values of 0.08 and 1.84 μM，respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing the human OATP1B1 and OATP1B3. Leoidin is an antibacterial agent against both Gram-positive and Gram-negative pathogens. Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) (IC50= 42 μM) and inhibits protein synthesis in bacterial. Leoidin can be isolated from L. gangaleoides[1][2]. | | Definition | ChEBI: 8,10-dichloro-3,9-dihydroxy-1,4,7-trimethyl-6-oxo-2-benzo[b][1,4]benzodioxepincarboxylic acid methyl ester is a carbonyl compound. | | References | [1] De Bruyn T, et al. Structure-based identification of OATP1B1/3 inhibitors. Mol Pharmacol. 2013 Jun;83(6):1257-67. DOI:10.1124/mol.112.084152
[2] Hu Y, et al. Discovery and Analysis of Natural-Product Compounds Inhibiting Protein Synthesis in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4820-9. DOI:10.1128/AAC.00800-16 |
| | LEOIDIN(SH) Preparation Products And Raw materials |
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