| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:NSC745887
CAS:54490-26-5
Purity:99% Remarks:Reach out to us for more information about custom solutions.
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 15002144251 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:NSC745887
CAS:54490-26-5
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
|
NSC745887 manufacturers
- NSC745887
-
- $1980.00
-
2026-04-20
- CAS:54490-26-5
- Purity:
- Supply Ability: 10g
|
| | NSC745887 Basic information |
| | NSC745887 Chemical Properties |
| Melting point | 241-242 °C(Solv: dichloromethane (75-09-2)) | | Boiling point | 491.6±40.0 °C(Predicted) | | density | 1.448±0.06 g/cm3(Predicted) | | pka | -2.36±0.20(Predicted) |
| | NSC745887 Usage And Synthesis |
| Uses | NSC745887 (compound 25) is an inhibitor that targets DNA topoisomerase cleavage, activates the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, and induces apoptosis in cancer cells. NSC745887 enhances γH2AX expression and causes DNA fragmentation leading to DNA damage[1][2]. | | References | [1] Fann LY, et al. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget. 2017 Dec 27;9(15):11922-11937. DOI:10.18632/oncotarget.23714
[2] Huang HS, et al. Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues. Bioorg Med Chem. 2009;17(21):7418-7428. DOI:10.1016/j.bmc.2009.09.033 |
| | NSC745887 Preparation Products And Raw materials |
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