BRD-K98645985
| 中文名稱 | BRD-K98645985 |
|---|---|
| 中文同義詞 | BRD-K98645985;化合物 T10605;化合物 BRD-K98645985;BRD-K98645985 |CAS 1357647-78-9 |
| 英文名稱 | BRD-K98645985 |
| 英文同義詞 | BRD-K98645985;BRD K98645985,BRD-K-98645985,BRDK98645985;Urea, N-(1-methylethyl)-N'-[(3S,6S,7R)-3,4,5,6,7,8,9,10-octahydro-7-methoxy-3,6,9-trimethyl-10-oxo-4-[[4-(2-pyridinyl)phenyl]methyl]-2H-1,4,9-benzoxadiazacyclododecin-12-yl]-;1-isopropyl-3-((3S,6S,7R)-7-methoxy-3,6,9-trimethyl-10-oxo-4-(4-(pyridin-2-yl)benzyl)-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1,4,9]oxadiazacyclododecin-12-yl)urea;1-Isopropyl-3-((3S,6S,7R)-7-methoxy-3,6,9-trimethyl-10-oxo-4-(4-(pyridin-2-yl)benzyl)-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1]oxa[4,9]diazacyclododecin-12-yl)urea |
| CAS號(hào) | 1357647-78-9 |
| 分子式 | C33H43N5O4 |
| 分子量 | 573.73 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 1357647-78-9.mol |
| 結(jié)構(gòu)式 |  |
BRD-K98645985 性質(zhì)
| 沸點(diǎn) | 699.4±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.20±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 13.73±0.46(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至淺棕色 |
BRD-K98645985 是一種 BAF (mammalian SWI/SNF) 轉(zhuǎn)錄阻遏的抑制劑，EC50 為 ~2.37 μM。BRD-K98645985 結(jié)合 ARID1A 特異的 BAF 復(fù)合物，防止核小體定位，并有效逆轉(zhuǎn) HIV-1 潛伏期，并且無 T 細(xì)胞毒性。
|
BAF transcriptional repression 2.37 μM (EC 50 ) |
HIV-1
|
BRD-K98645985 (30 μM; 18 hours) treatment shows a 5-fold increase in
Bmi1
, 2.6-fold increase in
Ring1
, and 3.3-fold decrease in
Fgf4
.
BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-114268 | BRD-K98645985 BRD-K98645985 | 1357647-78-9 | 1mg | 5000元 |
| 2025/05/22 | HY-114268 | BRD-K98645985 BRD-K98645985 | 1357647-78-9 | 10 mM * 1 mLin DMSO | 31555元 |