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Product Name:AMiphenazole
CAS:490-55-1
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Product Name:Amiphenazole
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| | amiphenazole Basic information |
| Product Name: | amiphenazole | | Synonyms: | amiphenazole;Amifenazole;Daftazol;Phenamizol;Phenamizole;2,4-Diamino-5-phenylthiazole;2,4-Thiazolediamine, 5-phenyl-;Amifenazol | | CAS: | 490-55-1 | | MF: | C9H9N3S | | MW: | 191.25 | | EINECS: | 2077138 | | Product Categories: | | | Mol File: | 490-55-1.mol |  |
| | amiphenazole Chemical Properties |
| Melting point | 163.5°C (rough estimate) | | Boiling point | 413.3±25.0 °C(Predicted) | | density | 1.1906 (rough estimate) | | refractive index | 1.5300 (estimate) | | pka | 5.12±0.10(Predicted) |
| | amiphenazole Usage And Synthesis |
| Originator | Aamphisol,RJR | | Definition | ChEBI: Amiphenazole is a member of thiazoles. | | Manufacturing Process | Thiourea reacted with α-bromophenylacetonitrile and as a result of this
reaction 2-(cyanophenylmethyl)isothiourea was obtained.
By cyclisation of the 2-(cyanophenylmethyl)isothiourea 2,4-diamino-5-
phenylthiazole (amiphenazol) was produced. | | Therapeutic Function | Respiratory stimulant, Barbiturate antagonist,
Morphine antagonist | | Synthesis Reference(s) | Journal of the American Chemical Society, 73, p. 4517, 1951 DOI: 10.1021/ja01154a005 | | Purification Methods | The thiazole crystallises from aqueous EtOH or water. Store it in the dark under N2. The hydrochloride has m 273-274o(dec) (from MeOH/EtOAc), and the picrate has m 189-191o(dec) (from H2O). [Davies et al. J Chem Soc 3491 1950, Dodson & Turner J Am Chem Soc 73 4517 1951, Beilstein 27 III/IV 5139.] |
| | amiphenazole Preparation Products And Raw materials |
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