ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Suppliers list
Company Name: HANGZHOU LAURET BIOTECHOLOGY CO.,LTD  Gold
Tel: 15306536782
Email: 3839324846@qq.com
Products Intro: Product Name:(S,R,S)-AHPC-C2-NH2
CAS:2241643-69-4
Purity:98% Package:100mg/RMB 2400
Company Name: Daicel Chiral Technologies (China)CO.,LTD  
Tel: 021-50460086-9 15921403865
Email: han_yajun@dctc.daicel.com
Products Intro: Product Name:VH032-C1-NH2
CAS:2241643-69-4
Purity:95% Package:250MG;1G Remarks:211456
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Tel: 13504435624
Email: 1927928688@qq.com
Products Intro: Product Name:(S,R,S)-AHPC-C2-NH2
CAS:2241643-69-4
Purity:98+ Package:1g
Company Name: Henan Mengtai Pharmaceutical Technology Co., Ltd  
Tel: 17634413542 17634854698;
Email: 1959525201@qq.com
Products Intro: Product Name:INDEX NAME NOT YET ASSIGNED
CAS:2241643-69-4
Purity:98% HPLC
Company Name: Dipag (Weinan) Biotechnology Co., Ltd  
Tel: 15114901355
Email: 1002921772@qq.com
Products Intro: Product Name:INDEX NAME NOT YET ASSIGNED
CAS:2241643-69-4
Purity:>98% Package:0.5g;1g;5g
L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Basic information
Product Name:L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
Synonyms:(2S,4R)-1-((S)-2-(3-aminopropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(S,R,S)-AHPC-C2-NH2;VH032-C1-NH2;(2S,4R)-1-[(2S)-2-(3-aminopropanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
CAS:2241643-69-4
MF:C25H35N5O4S
MW:501.64
EINECS:
Product Categories:
Mol File:2241643-69-4.mol
L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Structure
L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Chemical Properties
Boiling point 814.5±65.0 °C(Predicted)
density 1.258±0.06 g/cm3(Predicted)
pka14.07±0.40(Predicted)
Safety Information
MSDS Information
L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Usage And Synthesis
Uses(S,R,S)-AHPC-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used inPROTACtechnology[1].
IC 50VHL
References[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery.Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Preparation Products And Raw materials
Raw materialsPropionamide-->Formamide-->Pyrrolidine-->Thiazole
Preparation ProductsLenalidomide-->Pomalidomide
Tag:L-Prolinamide, β-alanyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-(2241643-69-4) Related Product Information
(S)-tert-butyl 2-((1R,2R)-3-((1S,2R)-1-hydroxy-1-phenylpropan-2-ylamino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate (S,R,S)-AHPC-PEG2-acid Mal-PEG8-acid 2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride