- Ilomastat
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- $41.00
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2026-06-05
- CAS:142880-36-2
- Purity: 98.18%
- Supply Ability: 10g
- Ilomastat
-
- $1.00
-
2019-12-23
- CAS:142880-36-2
- Min. Order: 100g
- Purity: 99%
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| | Ilomastat Basic information |
| Product Name: | Ilomastat | | Synonyms: | (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-butanediamide Ilomastat (GM6001, Galardin);Galardin
CS 610;Ilomastat, >=98%;(r)-n4-hydroxy-n1-[(s)-2-(1h-indol-3-yl)-1-methylcarbamoly-ethyl]-2-isobutyl-succinamide;galardin tm;(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide;Galardin, GM6001, Ilomastat;SANTACRUZ | | CAS: | 142880-36-2 | | MF: | C20H28N4O4 | | MW: | 388.46 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 142880-36-2.mol |  |
| | Ilomastat Chemical Properties |
| density | 1.228±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO, and 100% ethanol. | | pka | 9.16±0.20(Predicted) | | form | Off-white solid | | color | White | | Sensitive | Moisture Sensitive | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | Cosmetics Ingredients Functions | CHELATING
SKIN CONDITIONING | | InChIKey | NITYDPDXAAFEIT-DYVFJYSZSA-N | | SMILES | CNC([C@@H](NC([C@@H](C(C)C)CC(NC)=O)=O)CC1=CNC2=CC=CC=C21)=O |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids |
| | Ilomastat Usage And Synthesis |
| Description | Ilomastat (142880-36-2) is a potent pan-specific inhibitor of matrix metalloproteinases (MMPs).1 Ki values have been reported for the following human MMPs: MMP-1, 0.4nM; MMP-2, 0.5nM; MMP-3, 27nM; MMP-7, 3.7nM; MMP-8, 0.1nM; MMP-9, 0.2nM; MMP-12, 3.6nM; MMP-14, 13.4nM; MMP-26, 0.36nM.2-4 Also inhibits MMP-10, MMP-13, MMP-15, MMP-17, MMP-20, MMP-21, TACE and ADAM19. | | Uses | Ilomastat is a metalloprotease inhibitor. | | Uses | GM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs). It inhibits zinc-containing thermolysin and elastase from P. aeruginosa, both with Ki values of 20 nM. GM 6001 inhibits MMP-1, -2, -7, -8, -9, -12, -13, -14, -16, and -26 with Ki or IC50 values between 0.1 and 10 nM. It inhibits disintegrin and metalloproteinase domain-containing (ADAM) proteins ADAM9, ADAM10, ADAM12, and ADAM17 at nanomolar concentrations. It less potently inhibits lethal factor from B. anthracis anthrax lethal toxin (Ki = 2.74 μM). GM 6001 also impairs the growth of the human pathogen Chlamydia by inhibiting peptide deformylase, which contains iron rather than zinc (IC50 = 38 nM). | | Definition | ChEBI: Ilomastat is an N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor It has a role as an EC 3.4.24.24 (gelatinase A) inhibitor, a neuroprotective agent, an anti-inflammatory agent, an antibacterial agent and an antineoplastic agent. It is a L-tryptophan derivative, a hydroxamic acid and a N-acyl-amino acid. | | General Description | A cell-permeable, potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice. | | Biochem/physiol Actions | GM6001 promotes cardiovascular and hepatocellular function. | | storage | Store at -20°C | | References | [1] ALAN SAGHATELIAN. Activity-based probes for the proteomic profiling of metalloproteases.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 27: 10000-10005. DOI:10.1073/pnas.0402784101
[2] RICHARD E. GALARDY. Low Molecular Weight Inhibitors in Corneal Ulcerationa[J]. Annals of the New York Academy of Sciences, 1994, 732 1: 315-323. DOI:10.1111/j.1749-6632.1994.tb24746.x
[3] MINORU YAMAMOTO. Inhibition of Membrane-Type 1 Matrix Metalloproteinase by Hydroxamate Inhibitors: An Examination of the Subsite Pocket[J]. Journal of Medicinal Chemistry, 1998, 41 8: 1209-1217. DOI:10.1021/jm970404a
[4] HYUN I PARK. The intermediate S1’ pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling.[J]. The Journal of Biological Chemistry, 2003, 278 51: 51646-51653. DOI:10.1074/jbc.m310109200 |
| | Ilomastat Preparation Products And Raw materials |
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