α-Muricholic Acid

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Products Intro: Product Name:α-Muricholic acid
CAS:2393-58-0
Purity:98.00% Package:5mg;987USD|1mg;293USD|10mg;1870USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:5β-Cholanic acid-3α,6β,7α-triol
CAS:2393-58-0
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CAS:2393-58-0
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Products Intro: Product Name:α-Muricholic Acid
CAS:2393-58-0
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Products Intro: Product Name:α-Muricholic Acid
CAS:2393-58-0
Purity:99% Package:1mg;5mg;10mg;50mg

α-Muricholic Acid manufacturers
α-Muricholic Acid Basic information
Product Name:α-Muricholic Acid
Synonyms:(3a,5b,6b,7a)-3,6,7-trihydroxy-Cholan-24-oic acid;a-Muricholic acid;alpha-Muricholate;Ursodeoxycholic Acid Impurity 29;α-Muricholic Acid;alfa-Muricholic Acid;DKPMWHFRUGMUKF-GDYCBZMLSA-N;2H5]-α-Muricholic Acid
CAS:2393-58-0
MF:C24H40O5
MW:408.58
EINECS:
Product Categories:Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
Mol File:2393-58-0.mol
α-Muricholic Acid Structure
α-Muricholic Acid Chemical Properties
Melting point 200-202 °C
Boiling point 565.7±40.0 °C(Predicted)
density 1.184±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka4.76±0.10(Predicted)
color White to Off-White
InChIKeyDKPMWHFRUGMUKF-GDYCBZMLSA-N
SMILES[H][C@@]12[C@]([C@](CC[C@@H](O)C3)(C)[C@]3([H])[C@H](O)[C@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC(O)=O
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
α-Muricholic Acid Usage And Synthesis
Descriptionα-Muricholic acid is a murine-specific primary bile acid. Dietary administration of soybean protein decreases fecal levels of α-muricholic acid in mice with high-fat diet-induced obesity which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids. Plasma, liver, and muscle levels of α-muricholic acid are increased in mice switched from a high-fat to low-fat diet.
Usesα-Muricholic Acid is an bile acid found in urine. Studies have linked α-Muricholic in the understanding of the complex signaling pathways of hepatic lipid abnormalities with type 2 diabetes and a treatment target for this condition.
DefinitionChEBI: Alpha-muricholic acid is a member of the class of muricholic acids in which the hydroxy groups at positions 6 and 7 have beta- and alpha- configuration respectively. It is a member of muricholic acids, a 6beta-hydroxy steroid and a 7alpha-hydroxy steroid. It is a conjugate acid of an alpha-muricholate.
in vivo

Sulfated and non-sulfated bile acids are determined in the intestines and in the feces of 7-month-old germ-free and conventional male mice. The major bile acids from germ-free mice are cholic acid, α-Muricholic acid and β-Muricholic acid[1].
In the context of primary bile acid, α-Muricholic acid is greatly reduced in high-fat diet (HFD)-soybean protein isolate (SPI) mice compared to the HFD controls[2].

References[1] HENDRIK J. EYSSEN  Jan A M  Guido G PARMENTIER. Sulfated Bile Acids in Germ-Free and Conventional Mice[J]. The FEBS journal, 1976, 66 3: 507-514. DOI: 10.1111/j.1432-1033.1976.tb10576.x
[2] TETSUYA UEHARA. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation.[J]. Transplantation, 2004, 78 3: 324-332. DOI: 10.1097/01.tp.0000128859.42696.28
[3] KEITA WATANABE. Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids.[J]. ACS Applied Bio Materials, 2018: e0202083. DOI: 10.1371/journal.pone.0202083
[4] MICHAEL R. LA FRANO . Diet-induced obesity and weight loss alter bile acid concentrations and bile acid–sensitive gene expression in insulin target tissues of C57BL/6J mice[J]. Nutrition Research, 2017, 46: Pages 11-21. DOI: 10.1016/j.nutres.2017.07.006
α-Muricholic Acid Preparation Products And Raw materials
Tag:α-Muricholic Acid(2393-58-0) Related Product Information
ω-Agatoxin TK Ursodeoxycholic acid Chenodeoxycholic acid 4-[(5S,7S,8S,10S,13R,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (4R)-4-[(3R,5R,8R,9S,10S,12R,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid URSODEOXYCHOLIC-2,2,4,4-D4 ACID Deoxyursocholic acid methyl ester (5a,7b)-7-hydroxy-3-oxo-Cholan-24-oic acid 7-Oxyisotithocholic Acid 3alpha-Hydroxy-7-oxo-5beta-cholanic Acid LITHOCHOLIC ACID 3,7-DIKETO-5BETA-CHOLAN-24-OIC ACID (3a,5b,7a,12b)-3,7,12-trihydroxy-Cholan-24-oic acid (3α,5β,7β)- 3,7,22-Trihydroxycholan-24-oic Acid (3b,5b,7a,12a)-3,7,12-trihydroxy-Cholan-24-oic acid (4R)-4-[(3S,5S,7S,8S,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (4R)-4-[(3S,5R,8S,9S,10S,12S,13R,14S)-1,3,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid