| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:RX 801077
CAS:72583-92-7
Purity:大于98% Package:1g,5g,10g,25g根據(jù)客戶需要分裝 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:RX 801077
CAS:72583-92-7
Purity:99.99% Package:5mg/RMB 3930;50mg/RMB 11000;25mg/RMB 8480
|
| Company Name: |
Aikon International Limited
|
| Tel: |
025-58851090 19370895928 |
| Email: |
2850281427@qq.com |
| Products Intro: |
Product Name:2-(Benzofuran-2-yl)-4,5-dihydro-1H-imidazole
CAS:72583-92-7
Purity:95%+ Package:1g;5g;10g
|
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Email: |
info@biorbyt.com |
| Products Intro: |
Product Name:RX 801077
CAS:72583-92-7
|
1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro- manufacturers
- RX 801077
-
- $1980.00
-
2026-04-20
- CAS:72583-92-7
- Purity: 99.99%
- Supply Ability: 10g
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| | 1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro- Basic information |
| | 1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro- Chemical Properties |
| | 1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro- Usage And Synthesis |
| Uses | RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI)[1][2]. | | Definition | ChEBI: 2-(2-benzofuranyl)-4,5-dihydro-1H-imidazole is a member of benzofurans. | | in vivo | RX 801077 (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury[2]. | Animal Model: | 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2] | | Dosage: | 5, 10, 20 mg/kg | | Administration: | I.p.; twice daily for 3 days | | Result: | Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex. |
| | References | [1] Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272(2):681-8. PMID:7853182
[2] Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674. |
| | 1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro- Preparation Products And Raw materials |
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