| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:TWIK-1/TREK-1-IN-2
CAS:1440532-32-0
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
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| Company Name: |
Hebei Yaocheng Pharmaceutical Technology Co. Ltd
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| Tel: |
19903117580 19903117510 |
| Email: |
yc-eliu@yaochengph.com |
| Products Intro: |
Product Name:(S)-1-([1,4'-bipiperidin]-1'-yl)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol
CAS:1440532-32-0
Purity:95% Package:5g100gkg級
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[1,4'-Bipiperidine]-1'-ethanol, α-[[4-(trifluoromethyl)phenoxy]methyl]-, (αS)- manufacturers
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| | [1,4'-Bipiperidine]-1'-ethanol, α-[[4-(trifluoromethyl)phenoxy]methyl]-, (αS)- Basic information |
| | [1,4'-Bipiperidine]-1'-ethanol, α-[[4-(trifluoromethyl)phenoxy]methyl]-, (αS)- Chemical Properties |
| Boiling point | 490.8±45.0 °C(Predicted) | | density | 1.198±0.06 g/cm3(Predicted) | | pka | 13.95±0.20(Predicted) |
| | [1,4'-Bipiperidine]-1'-ethanol, α-[[4-(trifluoromethyl)phenoxy]methyl]-, (αS)- Usage And Synthesis |
| Uses | TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. TWIK-1/TREK-1-IN-2 inhibits TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 10.13 μM and 15.5 μM. TWIK-1/TREK-1-IN-2 is an antidepressant[1]. | | References | [1] Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139. DOI:10.1016/j.biopha.2023.115139 |
| | [1,4'-Bipiperidine]-1'-ethanol, α-[[4-(trifluoromethyl)phenoxy]methyl]-, (αS)- Preparation Products And Raw materials |
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