款冬酮
| 中文名稱(chēng) | 款冬酮 |
|---|---|
| 中文同義詞 | 款冬素,款冬花素,款冬花酮;款冬素,款冬花素;款冬酮(款冬素,款冬花素,款冬花酮;款冬酮, 來(lái)源于款冬花;款冬酮(分析標(biāo)準(zhǔn)品);款冬素;款冬酮(款冬素;款冬酮 |
| 英文名稱(chēng) | Tussilagone |
| 英文同義詞 | Tussilagone;L 652469;Tussilagone, 98%, from Farfarae Flos;2-Pentenoic acid, 3-methyl-, (1S,3aR,5R,7S,7aS)-1-[(1R)-1-(acetyloxy)ethyl]octahydro-4-methylene-7-(1-methylethyl)-2-oxo-1H-inden-5-yl ester, (2E)-;(1R,3aR,5R,7S,7aS)-1-(1-acetyloxyethyl)-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydro-1H-inden-5-yl](E)-3-methylpent-2-enoate;(1S,3aR,5R,7S,7aS)-1-((R)-1-Acetoxyethyl)-7-isopropyl-4-methylene-2-oxooctahydro-1H-inden-5-yl (E)-3-methylpent-2-enoate;Tussilagone-RM;Tussilagone (Standard) |
| CAS號(hào) | 104012-37-5 |
| 分子式 | C23H34O5 |
| 分子量 | 390.51 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | 標(biāo)準(zhǔn)品;對(duì)照品;中藥對(duì)照品;分析試劑標(biāo)準(zhǔn)品;對(duì)照品-中藥對(duì)照品;倍半萜;標(biāo)準(zhǔn)品，對(duì)照品 |
| Mol文件 | 104012-37-5.mol |
| 結(jié)構(gòu)式 |  |
款冬酮 性質(zhì)
| 沸點(diǎn) | 471.3±35.0 °C(Predicted) |
|---|---|
| 密度 | 1.07±0.1 g/cm3 (20 ºC 760 Torr) |
| 儲(chǔ)存條件 | 2-8°C |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| InChIKey | CFUPNMDNSQIWBB-UUVDBSHOSA-N |
| SMILES | C(O[C@@H]1C[C@@H](C(C)C)[C@@]2([H])[C@]([H])(C1=C)CC(=O)[C@@H]2[C@H](OC(C)=O)C)(=O)/C=C(\C)/CC |
Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages. Tussilagone also reduced the activation of the mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) involved in the activation of various inflammatory mediators in activated macrophages.
Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration.
藥理藥效:有升壓、呼吸興奮作用
安全信息
| 安全說(shuō)明 | 24/25 |
|---|---|
| WGK Germany | WGK 3 |
| 海關(guān)編碼 | 29389090 |
| 存儲(chǔ)類(lèi)別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | S9180 | 款冬酮 Tussilagone | 104012-37-5 | 1mg | 1286.2元 |
| 2026/06/05 | HY-N1388 | 款冬酮 Tussilagone | 104012-37-5 | 1 mg | 480元 |