DUP 105
| 中文名稱 | DUP 105 |
|---|---|
| 中文同義詞 | 化合物 T11123;化合物DUP 105;化合物DUP 105,10 MM DMSO 溶液 |
| 英文名稱 | 4-methylsulfinylphenyloxooxazolidinylmethylacetamide |
| 英文同義詞 | 4-methylsulfinylphenyloxooxazolidinylmethylacetamide;(5S)-5-Acetylaminomethyl-3-(4-methylsulfinylphenyl)oxazolidin-2-one;DuP-105;N-[[(5S)-3-[4-(Methylsulfinyl)phenyl]-2-oxooxazolidin-5-yl]methyl]acetamide;Acetamide, N-[[(5S)-3-[4-(methylsulfinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-;(S)-N-<<3-<4(S)-(methylsulfinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide;DuP 105, 10 mM in DMSO;N-[[(5S)-3-(4-Methylsulfinylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide |
| CAS號 | 96800-41-8 |
| 分子式 | C13H16N2O4S |
| 分子量 | 296.34 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 96800-41-8.mol |
| 結構式 |  |
DUP 105 性質
| 熔點 | 185.1-185.8 °C |
|---|---|
| 沸點 | 574.393±33.00 °C(Press: 760.00 Torr)(predicted) |
| 密度 | 1.403±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | Solid |
| 酸度系數(shù)(pKa) | 15.527±0.46(predicted) |
| 顏色 | White to off-white |
DuP 105 是一種可口服的惡唑烷酮類化合物，能夠抗葛蘭素陽性菌。
DuP 105 shows inhibitory activities against staphylococcal isolates and B. fragilis isolates with MIC 90 s of 4 to 16 μg/mL and 16 μg/mL. DuP 105 MICs for 50% of the 216 gram-positive isolates tested (MIC 50 s) range from 4.0 to 16 μg/mL.
DuP 105 administered by either the oral or the parenteral route is protective against staphylococcal and streptococcal infections in mice with the 50% effective doses of 9 to 23 mg/kg.