| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:PROTAC BTK Degrader-12
CAS:2736508-65-7
Purity:98%HPLC Package:10mg，100mg，500mg，1g，2g，5g，10g，more
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| | BGB-116673 Basic information |
| Product Name: | BGB-116673 | | Synonyms: | BGB-116673;(R)-3-(tert-butyl)-N-(1-(4-(6-(5-(4-((1-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-methylphenyl)ethyl)-1,2,4-oxadiazole-5-carboxamide;(R)-3-(tert-butyl)-N-(1-(4-(6-(5-(4-((1-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2-methylphenyl)ethyl)-1,2,4;PROTAC BTK Degrader-12;PROTAC BTK Degrader | | CAS: | 2736508-65-7 | | MF: | C47H54N12O4 | | MW: | 851.01 | | EINECS: | | | Product Categories: | | | Mol File: | 2736508-65-7.mol |  |
| | BGB-116673 Chemical Properties |
| density | 1.284±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | | pka | 7.48±0.50(Predicted) |
| | BGB-116673 Usage And Synthesis |
| Uses | PROTAC BTK Degrader-12 (EXAMPLE 19) is a PROTAC-based BTK degrader (Pink & black: BTK ligand & linker (HY-170414); Black: linker (HY-30105); Blue: VHL ligand ( HY-W245311))[1]. | | References | [1] Hexiang Wang, et al. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use. Patent WO2021219070A1. |
| | BGB-116673 Preparation Products And Raw materials |
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