| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:5-((9-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-9-oxononyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:2864408-92-2
Purity:98% Package:10mg;25mg;50mg;100mg;250mg Remarks:BD02193773
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| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:GBD-9
CAS:2864408-92-2
Purity:98%+ HPLC Package:10mg，100mg，500mg，1g，2g，5g，10g，more
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| Company Name: |
Selleck Chemicals
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| Tel: |
400-668-6834 |
| Email: |
info@selleck.cn |
| Products Intro: |
Product Name:GBD-9
CAS:2864408-92-2
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| Product Name: | GBD-9 | | Synonyms: | GBD-9;5-({9-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-9-oxononyl}amino)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 5-[[9-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-9-oxononyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;5-((9-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-9-oxononyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;5-[[9-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-9-oxononyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | | CAS: | 2864408-92-2 | | MF: | C44H47N9O6 | | MW: | 797.9 | | EINECS: | | | Product Categories: | | | Mol File: | 2864408-92-2.mol |  |
| | GBD-9 Chemical Properties |
| Boiling point | 1045.8±65.0 °C(predicted) | | density | 1.43±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 10.81±0.40(predicted) | | form | Solid | | color | Light yellow to green yellow |
| | GBD-9 Usage And Synthesis |
| Uses | GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth[1]. | | IC 50 | Cereblon | | References | [1] Zimo Yang, et al. Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently. Cell Res. 2021 Dec;31(12):1315-1318. DOI:10.1038/s41422-021-00533-6 |
| | GBD-9 Preparation Products And Raw materials |
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