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| | 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Basic information |
| Product Name: | 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one | | Synonyms: | Entecavir InterMediate VIII IsoMer;Entecavir InterMediate N-1;[1S-(1α,3α,4β)]-2-AMino-1,9-dihydro-9-[2-Methylene-4-(phenylMethoxy)-3-[(phenylMethoxy)Methyl]cyclopentyl]-6H;2-AMino-1,9-dihydro-9-[(1S,3R,4S)-2-Methylene-4-(phenylMethoxy)-3-[(phenylMethoxy)Methyl]cyclopentyl]-6H-purin-6-one;3',5'-Di-O-benzyl Entecavir;2-AMino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxyMethyl)-2-Methylenecyclopentyl]-6H-purin-6-one (interMediate 7);2-AMino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxyMethyl)-2-Methylenecyclopentyl]-6H-purin;2-Amino-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)-methyl)-2-methylenecyclopentyl)-1H-purin-6(9H) | | CAS: | 142217-81-0 | | MF: | C26H27N5O3 | | MW: | 457.52 | | EINECS: | 1312995-182-4 | | Product Categories: | | | Mol File: | 142217-81-0.mol | ![2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Structure](CAS/GIF/142217-81-0.gif) |
| | 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Chemical Properties |
| Melting point | 245-247°C (dec.) | | density | 1.34 | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly) | | form | Solid | | pka | 9+-.0.20(Predicted) | | color | White to Pale Beige | | CAS DataBase Reference | 142217-81-0(CAS DataBase Reference) |
| | 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Usage And Synthesis |
| Chemical Properties | White powder | | Uses | 3’,5’-Di-O-benzyl Entecavir is an intermediate in the preparation of the hepatitis B antiviral agent, Entecavir (E558900). | | Uses | 3’5’Di-O-benzyl Entecavir is an intermediate in the preparation of the hepatitis B antiviral agent, Entecavir (E558900). |
| | 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one Preparation Products And Raw materials |
| Raw materials | Benzene, [(2,4-cyclopentadien-1-ylmethoxy)methyl]--->(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(benzyloxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanone-->(1S,2R,3S,5R)-2-(Benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-ol-->SODIUM CYCLOPENTADIENIDE-->(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane-->6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine-->(1S, 2R)-2-(Benzyloxymethyl)-1-hydroxy-3-cyclopentene-->(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol-->(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol-->Benzyl chloromethyl ether-->Triethyl orthoformate |
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