5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER manufacturers
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| | 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER Basic information |
| Product Name: | 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER | | Synonyms: | 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER;Methyl 5-bromoindole-7-carboxylate;5-BroMo-1H-indol-7-carboxylic acid Methyl ester;1H-Indole-7-carboxylic acid, 5-bromo-, methyl ester;5-Bromo-1H-indole-7-carboxylic acid methyl ester;1H-Indole-7-carboxylic acid, 5-bromo-, methyl ester (9CI, ACI);5-bromo-1H-Indole-7-carboxylic acid methyl ester (9CI ACI);methyl 5-bromo-1H-indole-7-carboxylate | | CAS: | 860624-89-1 | | MF: | C10H8BrNO2 | | MW: | 254.08 | | EINECS: | | | Product Categories: | | | Mol File: | 860624-89-1.mol |  |
| | 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER Chemical Properties |
| Boiling point | 382.6±22.0 °C(Predicted) | | density | 1.629±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 14.46±0.30(Predicted) | | Appearance | Light yellow to brown Solid | | CAS DataBase Reference | 860624-89-1 |
| | 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER Usage And Synthesis |
| Synthesis | Iodomethane (7.81 mL, 125 mmol) was slowly added dropwise to a solution of N,N-dimethylformamide (50 mL) containing 5-bromo-1H-indole-7-carboxylic acid (10 g, 41.7 mmol) and sodium carbonate (17.66 g, 167 mmol). The reaction mixture was stirred continuously for 2 h at room temperature. Upon completion of the reaction, it was filtered through a silica gel pad (500 g) and eluted with ether (600 mL). The collected eluate was washed once with deionized water (100 mL) and subsequently concentrated under reduced pressure to afford methyl 5-bromoindole-7-carboxylate (9.65 g, 91% yield). The product was confirmed by LC/MS analysis: m/z 253.8 (M+), retention time 2.15 min. | | References | [1] Patent: WO2008/118724, 2008, A1. Location in patent: Page/Page column 69-70
[2] ACS Medicinal Chemistry Letters, 2018, |
| | 5-BROMO INDOLE-7-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials |
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