Scillascillin manufacturers
- Scillascillin
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- $1.00
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2020-03-13
- CAS:52706-07-7
- Min. Order: 1KG
- Purity: 98% HPLC
- Supply Ability: 10 tons
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| | Scillascillin Basic information |
| Product Name: | Scillascillin | | Synonyms: | (R)-5,7-Dihydroxyspiro[2H-1-benzopyran-3(4H),5'(6'H)-cyclobuta[f][1,3]benzodioxol]-4-one;Scillascillin;Scylin;Spiro[2H-1-benzopyran-3(4H),5'(6'H)-cyclobuta[f][1,3]benzodioxol]-4-one, 5,7-dihydroxy-, (3R)- | | CAS: | 52706-07-7 | | MF: | C17H12O6 | | MW: | 312.27 | | EINECS: | | | Product Categories: | | | Mol File: | 52706-07-7.mol |  |
| | Scillascillin Chemical Properties |
| Boiling point | 607.3±55.0 °C(Predicted) | | density | 1.69 g/cm3 | | pka | 7.11±0.20(Predicted) |
| | Scillascillin Usage And Synthesis |
| Uses | Scillascillin (compound 10) is a homoisoflavanone. Scillascillin can be isolated from S. scilloides. Scillascillin shows anticancer activity towards MCF-7 (breast cancer) and DU-145 (prostate cancer) cells with the IC50 of 9.59 and 11.32 ug/ml, respectively[1][2]. | | Synthesis | The dried whole herb powder of Mianzhaoer was extracted with 95% industrial ethanol for three times at room temperature for 3 d each time, and about 1,936 g of extract was obtained, which was separated by silica gel column chromatography, and 10 fragments were obtained by petroleum ether-acetone elution (Fr. 1-10), and Fr. 3 (petroleum ether-acetone 9010) was repeatedly combined with Sephadex LH-20 (chloroform-methanol 11) to obtain compound 1 (323 mg), 3 (45 mg), 4 (12 mg), which was white powder. Sephadex LH-20 (chloroform-methanol 1:1) to obtain compounds 1 (323 mg), 3 (45 mg), 4 (12 mg); Compound 1: white powder, NMR data and literature reports are consistent, so the identification of Compound 1 is Mianzhaoeruin. | | References | [1] Yoichiro Nishida, et al. A new homostilbene and two new homoisoflavones from the bulbs of Scilla scilloides. Chem Pharm Bull (Tokyo). 56, 7. DOI:10.1248/cpb.56.1022
[2] Chinthala Y, et al. Anticancer Active Homoisoflavone from the Underground Bulbs of Ledebouria hyderabadensis. Pharmacognosy Res. 2014;6(4):303-305. DOI:10.4103/0974-8490.138272 |
| | Scillascillin Preparation Products And Raw materials |
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