- LY294002
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- $34.00
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2026-05-11
- CAS:154447-36-6
- Purity: 99.89%
- Supply Ability: 10g
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| | LY 294002 Hydrochloride Basic information | | Background |
| | LY 294002 Hydrochloride Chemical Properties |
| Melting point | 183-185℃ | | Boiling point | 494.6±45.0 °C(Predicted) | | density | 1.266 | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO: >5 mg/mL | | form | solid | | pka | 0.55±0.20(Predicted) | | color | white to off-white | | Water Solubility | Soluble in DMSO at 5mg/ml. Insoluble in water | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. | | InChI | InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 | | InChIKey | CZQHHVNHHHRRDU-UHFFFAOYSA-N | | SMILES | C1(N2CCOCC2)OC2=C(C3=CC=CC=C3)C=CC=C2C(=O)C=1 | | CAS DataBase Reference | 154447-36-6 |
| Safety Statements | 24-25 | | WGK Germany | 3 | | HS Code | 29349990 | | Storage Class | 10 - Combustible liquids |
| | LY 294002 Hydrochloride Usage And Synthesis |
| Description | LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM. | | Uses | LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice. | | Uses | A potent blocker of PI 3-kinase/Akt signaling. | | Uses | LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590). | | Definition | ChEBI: LY294002 is a chromone substituted with a phenyl group at position 8 and a morpholine group at position 2. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, an autophagy inhibitor and a geroprotector. It is a member of chromones, a member of morpholines and an organochlorine compound. | | Biological Activity | A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo . | | target | p110α | | Background | LY294002 was shown to act in vivo as a highly selective inhibitor of phosphatidylinositol 3 kinase. When used at a concentration of 50 μM, it specifically abolished PI3 kinase activity but did not inhibit other lipid and protein kinases such as PI4 kinase, PKC, MAP kinase or c-Src. LY294002 is soluble in DMSO or ethanol. For use with in vitro or cell-based assays, it may be diluted into aqueous buffers to yield the desired concentrations. | | References | [1] C. VLAHOS. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).[J]. The Journal of Biological Chemistry, 1994, 93 1: 5241-5248. DOI:10.1016/s0021-9258(17)37680-9.
[2] SEVERINE I GHARBI. Exploring the specificity of the PI3K family inhibitor LY294002.[J]. ACS Applied Energy Materials, 2007: 15-21. DOI:10.1042/BJ20061489.
[3] SANCHEZMARGALET V. Role of Phosphatidylinositol-3-Kinase in Insulin Receptor Signaling: Studies with Inhibitor, LY294002[J]. Biochemical and biophysical research communications, 1994, 204 2: Pages 446-452. DOI:10.1006/bbrc.1994.2480. |
| | LY 294002 Hydrochloride Preparation Products And Raw materials |
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