- Su1498
-
- $34.00
-
2026-05-11
- CAS:168835-82-3
- Purity: 99.89%
- Supply Ability: 10g
|
| | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Basic information |
| | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Chemical Properties |
| Melting point | 126 °C | | Boiling point | 590.6±50.0 °C(Predicted) | | density | 1.100±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO. | | pka | 10.30±0.36(Predicted) | | form | powder | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | | InChI | 1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+ | | InChIKey | JANPYFTYAGTSIN-FYJGNVAPSA-N | | SMILES | N(CCCc2ccccc2)C(=O)\C(=C\c1cc(c(c(c1)C(C)C)O)C(C)C)\C#N | | CAS DataBase Reference | 168835-82-3 |
| WGK Germany | WGK 3 | | HS Code | 2926.90.4801 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Usage And Synthesis |
| Description | SU-1498 (168835-82-3) is a potent, reversible, selective inhibitor of VEGFR-2, also known as Flk-1 (IC50 = 700 nM). Inhibition of VEGFR-2 blocks angiogenesis in both in vitro and in vivo models. Cell permeable. | | Uses | SU 1498 is an inhibitor of VEGF receptor kinase. | | Definition | ChEBI: SU1498 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enoic acid with the amino group of 3-phenylpropylamine. It has a role as a vascular endothelial growth factor receptor antagonist. It is an enamide, a member of phenols, a nitrile, a monocarboxylic acid amide and a secondary carboxamide. | | Biochem/physiol Actions | SU1498 is a potent and selective inhibitor of the VEGFR2 receptor kinase, Flk-1 with an IC50 value of 700 nM. SU1498 is a very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase with IC50 values > 50 μM. SU1498 has been used to study the role of VEGFR2 (Flk-1) in a variety of biological activities including angiogenesis, tumor growth inhibition, and stem cell proliferation. | | IC 50 | Flk-1: 700 nM (IC50) | | References | [1] SU JIN CHO. Retinoic acid and erythropoietin maintain alveolar development in mice treated with an angiogenesis inhibitor.[J]. American Journal of Respiratory Cell and Molecular Biology, 2005, 33 6: 622-628. DOI:10.1165/rcmb.2005-0050oc
[2] YINGXIAO WANG. Interplay between integrins and FLK-1 in shear stress-induced signaling.[J]. American journal of physiology. Cell physiology, 2002, 283 5: C1540-7. DOI:10.1152/ajpcell.00222.2002
[3] L M STRAWN. Flk-1 as a target for tumor growth inhibition.[J]. Cancer research, 1996, 56 15: 3540-3545. |
| | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Preparation Products And Raw materials |
|