5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
| 中文名稱 | 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime |
|---|---|
| 中文同義詞 | 5'-氟-3-(肟基)-[2,3'-雙吲哚亞基]-2'-酮;化合物5'-FLUOROINDIRUBINOXIME;5'-氟二異丁酮肟;化合物 5'-FLUOROINDIRUBINOXIME;化合物5'-FLUOROINDIRUBINOXIME,10 MM DMSO 溶液;5'-FLUOROINDIRUBINOXIME (5'-FIO);5'-Fluoroindirubinoxime 試劑;5'-Fluoroindirubinoxime ,S0550 |
| 英文名稱 | 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime |
| 英文同義詞 | 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime;5'-Fluoroindirubinoxime;-Fluoroindirubinoxime;5'-FIO;2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro-;FLT3,HT-1080,CD135,A549,Cluster of differentiation antigen 135,RK3E-ras,SNU-638,Fms like tyrosine kinase 3,Inhibitor,5'Fluoroindirubinoxime,inhibit,5' Fluoroindirubinoxime,5'-Fluoroindirubinoxime;PD 082106;5''-Fluoroindirubinoxime |
| CAS號 | 861214-33-7 |
| 分子式 | C16H10FN3O2 |
| 分子量 | 295.27 |
| EINECS號 | |
| 相關類別 | 標準品 |
| Mol文件 | 861214-33-7.mol |
| 結構式 | ![5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 結構式](CAS/GIF/861214-33-7.gif) |
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 性質
| 熔點 | 296 °C |
|---|---|
| 沸點 | 528.3±50.0 °C(Predicted) |
| 密度 | 1.57±0.1 g/cm3(Predicted) |
| 儲存條件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMSO：83.33 mg/mL（282.22 mM；需要超聲波） |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 8.48±0.20(Predicted) |
| 顏色 | 淺棕色至黑色 |
5'-Fluoroindirubinoxime (compound 13) 是Indirubin (HY-N0117) 的衍生物，是FLT3 的抑制劑，其IC50 值為15 nM。
15 nM (FLT3).
5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC
50
values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.
5'-Fluoroindirubinoxime (5’-FIO) exhibits IC
50
values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.
5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats.
| Animal Model: | Rat tumor model based RK3E-ras cells. |
| Dosage: | S.C.. |
| Administration: | 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6. |
| Result: | Effectively inhibited tumor growth. |
安全信息
| 更新日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0550 | 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 5'-Fluoroindirubinoxime | 861214-33-7 | 5mg | 3497.13元 |
| 2026/07/06 | S0550 | 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 5'-Fluoroindirubinoxime | 861214-33-7 | 25mg | 10556.9元 |