CINACIGUAT
| 中文名稱 | CINACIGUAT |
|---|---|
| 中文同義詞 | GUANYLATE CYCLASE激活劑(CINACIGUAT);4-[[(4-羧基丁基)[2-[2-[[4-(2-苯基乙基)苯基]甲氧基]苯基]乙基]氨基]甲基]苯甲酸;化合物CINACIGUAT;4-(((4-羧丁基)(2((4-苯乙基芐基)氧基)苯乙基)氨基)甲基)苯甲酸;BAY 58-2667游離堿;CINACIGUAT,鳥(niǎo)苷酸環(huán)化酶 (GC) 活化劑;化合物CINACIGUAT,10 MM DMSO 溶液;Cinaciguat,鳥(niǎo)苷酸環(huán)化酶 (GC) 活化劑 ≥98% |
| 英文名稱 | 4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid |
| 英文同義詞 | 4-[N-(4-Carboxybutyl)-N-[2-[2-[4-(2-phenylethyl)benzyloxy]phenyl]ethyl]aMinoMethyl]benzoic acid;BAY 58-2667;4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid;Cinaciguat BAY-58-2667;CS-778;Benzoic acid, 4-[[(4-carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-;4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoic acid;Cinaciguat,Inhibitor,inhibit,Guanylate Cyclase |
| CAS號(hào) | 329773-35-5 |
| 分子式 | C36H39NO5 |
| 分子量 | 565.7 |
| EINECS號(hào) | |
| 相關(guān)類別 | 小分子抑制劑;小分子抑制劑，天然產(chǎn)物;細(xì)胞生物學(xué)試劑;Inhibitors |
| Mol文件 | 329773-35-5.mol |
| 結(jié)構(gòu)式 |  |
CINACIGUAT 性質(zhì)
| 儲(chǔ)存條件 | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米白色 |
Cinaciguat (10 μM) significantly enhances intracellular cGMP generation. Cinaciguat does not dose-dependent effects on cell contraction and calcium transients.
Cinaciguat (10 mg/kg/day, p.o.) treatment in diabetic rats does not influence blood glucose levels, but leads to attenuated water intake. Cinaciguat treatment alleviates diabetes mellitus related oxidative stress, protects against DM related alteration of the NO-sGC-cGMP-PKG signalling, and alleviates DM related myocardium hypertrophy and apoptosis. Cinaciguat (1-10-100 nM) induces concentration-dependent relaxations in strips from both WT and apo-sGC mice, but does not have any effect on phasic activity induced by PGF 2α in WT or apo-sGC strips.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-14181R | CINACIGUAT Cinaciguat (Standard) | 329773-35-5 | 1 mg | 1100元 |
| 2026/06/05 | HY-14181R | CINACIGUAT Cinaciguat (Standard) | 329773-35-5 | 5 mg | 2200元 |