| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:(±)14(15)-EET-SI
CAS:218461-97-3
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:(±)14(15)-EET-SI
CAS:218461-97-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:(±)14(15)-EET-SI
CAS:218461-97-3
Purity:98% Package:25ug (solution); 50ug (solution); 100ug (solution) Remarks:Medbio
|
(±)14(15)-EET-SI manufacturers
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| | (±)14(15)-EET-SI Basic information |
| Product Name: | (±)14(15)-EET-SI | | Synonyms: | (±)14(15)-EET-SI;5,8,11-Tridecatrienamide, N-(methylsulfonyl)-13-(3-pentyl-2-oxiranyl)-, (5Z,8Z,11Z)-;(±)14(15)-EET-SI | | CAS: | 218461-97-3 | | MF: | C21H35NO4S | | MW: | 397.57 | | EINECS: | | | Product Categories: | | | Mol File: | 218461-97-3.mol |  |
| | (±)14(15)-EET-SI Chemical Properties |
| density | 1.060±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml | | pka | 4.63±0.40(Predicted) |
| | (±)14(15)-EET-SI Usage And Synthesis |
| Description | Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch.1 (±)14(15)-EET-SI is the methyl sulfonamide analog of 14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to β-oxidation or membrane esterification. (±)14(15)-EET-SI is equipotent to 14(15)-EET in vascular agonist activity as measured by relaxation of precontracted bovine coronary arteries.1 In addition, 14(15)-EET and the methyl sulfonamide analog both stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.2 | | Uses | 14,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA[1]. | | References | 1. Gauthier, K.M., Falck, J.R., Reddy, L.M., et al. 14,15-EET analogs: Characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries Pharmacol. Res. 49(6),515-524(2004).
2. Chen, J.K., Falck, J.R., Reddy, K.M., et al. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells J. Biol. Chem. 273(44),29254-29261(1998). |
| | (±)14(15)-EET-SI Preparation Products And Raw materials |
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