| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2)
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2)
Remarks:13492
|
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| | Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2) Basic information |
| | Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2) Chemical Properties |
| | Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2) Usage And Synthesis |
| Description | The androgen receptor (AR) is an ~100 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy’s disease, and male infertility. The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. IGF-1 activates the PI3K/AKT pathway in LNCap at high passage number and increases phosphorylation of the AR at Ser213/210 and Ser791/790.1 The western blot results also show that inhibition of the PI3K/Akt pathway by LY294002 prior to incubation with IGF-1 suppressed AR phosphorylation at Ser213/210. Activation of the PI3K/Akt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis.WARNING This product is not for human or veterinary use. |
| | Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2) Preparation Products And Raw materials |
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