LP-261

LP-261 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:LP-261
CAS:915412-67-8
Purity:99.76% Package:5mg;43USD|10mg;73USD|25mg;118USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:LP-261
CAS:915412-67-8
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:LP-261
CAS:915412-67-8
Purity:99% Package:$42.9/1mg;$90.9/5mg;$150.9/10mg;$250.9/25mg;$450.9/50mg;$750.9/100mg;Bulk packag Remarks:99%
Company Name: WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.  
Tel: 17702719238
Email: sales@sun-shinechem.com
Products Intro: Product Name:LP-261
CAS:915412-67-8
Purity:98% HPLC Package:50.0mg;100.0mg; 200.0mg;500mg;1g;5g; 10g
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Products Intro: Product Name:LP-261
CAS:915412-67-8
Purity:99% Remarks:Reach out to us for more information about custom solutions.

LP-261 manufacturers

  • LP-261
  • LP-261 pictures
  • $72.00
  • 2026-05-25
  • CAS:915412-67-8
  • Purity: 99.91%
  • Supply Ability: 10g
LP-261 Basic information
Product Name:LP-261
Synonyms:LP-261;N-[3-(1H-indol-4-yl)-5-(2-methoxypyridine-4-carbonyl)phenyl]methanesulfonamide;NCI-H522,tubulin polymerization,tumor,SW-620,BXPC-3,H522,anti-mitotic,inhibit,LP261,MCF-7,Inhibitor,Microtubule/Tubulin,LP 261,cancer,Jurkat,LP-261;Methanesulfonamide, N-[3-(1H-indol-4-yl)-5-[(2-methoxy-4-pyridinyl)carbonyl]phenyl]-;LP-261, 10 mM in DMSO
CAS:915412-67-8
MF:C22H19N3O4S
MW:421.47
EINECS:
Product Categories:
Mol File:915412-67-8.mol
LP-261 Structure
LP-261 Chemical Properties
Boiling point 700.6±70.0 °C(Predicted)
density 1.391±0.06 g/cm3(Predicted)
pka6.72±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
LP-261 Usage And Synthesis
UsesLP-261 is a potent and orally active anti-mitotic agent and shows an inhibition of in vitro tubulin polymerization with an EC50 of 3.2 μM[1]. LP-261 inhibits growth of a human non-small-cell lung tumor (NCI-H522) in vivo and can be used for cancer research[1].
in vivo

LP-261 (oral gavage; 4 mg/kg; single dose) displays rapid adsorption by the oral route (Tmax=2.0 h), the terminal half-life of 1.4 h ( 0.2 h indicated a moderate rate of elimination in rat, and the volume of distribution (Vss) is 1.25 L/kg[1].LP-261 (oral gavage; 15 or 50 mg/kg; twice daily; 28 days) at 50mg/kg results in an approximately tumor volume of 130 mm3 versus 3769 mm3 in the vehicle treated group, this represents a 96% reduction in mean tumor volume. Meanwhile, LP-261 at 15 mg/kg leads to a 41% inhibition after 28 days in this mouse model[1].

Animal Model:Human tumor xenograft model (Injected with NCI-H522 human non-small-cell) in NCr-nu mice[1]
Dosage:15 or 50 mg/kg
Administration:Oral gavage; 15 or 50 mg/kg; twice daily; 28 days
Result:Had potent anti-tumor efficacy at high dosage and exhibited no significant changes in body weights.
References[1] Rupa S Shetty, et al. Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent. J Med Chem. 2011 Jan 13;54(1):179-200 DOI:10.1021/jm100659v
LP-261 Preparation Products And Raw materials
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