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| | 1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Basic information |
| Product Name: | 1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- | | Synonyms: | 1-(tetrahydrofuran-3-yl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Tetrahydrofuran-3-yl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-(3-Tetrahydrofuryl)-1H-pyrazole-4-boronic acid pinacol ester;1-(oxolan-3-yl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Tetrahydrofuran-3-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol;1-(Oxolan-3-yl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 95+%;1-(Oxolan-3-yl)-1H-pyrazole-4-boronic acid pinacol ester;1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- | | CAS: | 1029715-63-6 | | MF: | C13H21BN2O3 | | MW: | 264.13 | | EINECS: | | | Product Categories: | | | Mol File: | 1029715-63-6.mol |  |
| | 1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Chemical Properties |
| Boiling point | 399.3±32.0 °C(Predicted) | | density | 1.18±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 2.63±0.19(Predicted) | | Appearance | Off-white to pink Solid |
| | 1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Usage And Synthesis |
| Synthesis | Potassium acetate (KOAc, 1.07 g, 10.92 mmol) was added to a solution of 4-bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole (0.79 g, 3.64 mmol) and pinacol ester of bis(boronic acid) (1.11 g, 4.37 mmol) in N,N-dimethylformamide (DMF, 20 mL). The reaction mixture was degassed with nitrogen (N2) and stirred for 10 min, followed by the addition of [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride (Pd(dppf)Cl2, 89 mg, 0.109 mmol). After degassing again with nitrogen, the reaction mixture was stirred at 80 °C overnight. After completion of the reaction, DMF was removed by rotary evaporation and the residue was purified by column chromatography (eluent ratio: ethyl acetate:petroleum ether = 1:10) to afford 1-(tetrahydrofuran-3-yl)-1H-pyrazole-4-boronic acid pinacol ester (0.63 g, 65.6% yield). | | References | [1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 46 |
| | 1H-Pyrazole, 1-(tetrahydro-3-furanyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Preparation Products And Raw materials |
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