- LY900009
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- $32.00
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2026-04-22
- CAS:209984-68-9
- Purity: 98.97%
- Supply Ability: 10g
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| | LY900009 Basic information |
| Product Name: | LY900009 | | Synonyms: | LY900009;(2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]amino]-1-oxopropan-2-yl]butanamide;LY900009/LY-900009;7-(S)-(N'-((S)-(+)-2-hydroxy-3-methylbutyryl)-L-alaninyl)amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one;(S)-2-hydroxy-3-methyl-N-((S)-1-(((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide;Butanamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-2-hydroxy-3-methyl-, (2S)-;LY900009, 10 mM in DMSO | | CAS: | 209984-68-9 | | MF: | C23H27N3O4 | | MW: | 409.48 | | EINECS: | | | Product Categories: | | | Mol File: | 209984-68-9.mol |  |
| | LY900009 Chemical Properties |
| Boiling point | 781.5±60.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | solubility | DMSO mg/mL Water mg/mL Ethanol mg/mL | | form | Powder | | pka | 12.73±0.20(Predicted) | | color | White to off-white |
| | LY900009 Usage And Synthesis |
| Uses | LY900009 is a potent and orally active, First-in-class inhibitor of Notch signaling via selective inhibition of the γ-secretase protein (GSI). LY900009 inhibits Notch signalling in tumor cell lines and endothelial cells (IC50=0.005-20 nM). LY900009 can be used for advanced cancer research[1]. | | in vivo | LY900009 (oral gavage; 3 mg/kg; single dosage) revealed inhibition of angiogenesis through formation of leaky vasculature and produced tumour regression in Notch-dependent tumour models in a rat model[1]. | | target | Notch | | References | [1] Shubham Pant, et al. A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer. Eur J Cancer. 2016 Mar;56:1-9. DOI:10.1016/j.ejca.2015.11.021 |
| | LY900009 Preparation Products And Raw materials |
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