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| | 4-amino-2-chloronicotinic acid Basic information |
| Product Name: | 4-amino-2-chloronicotinic acid | | Synonyms: | 4-amino-2-chloronicotinic acid;4-amino-2-chloropyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 4-amino-2-chloro-;4-amino-2-chloro-3-Pyridinecarboxylic acid | | CAS: | 1018678-38-0 | | MF: | C6H5ClN2O2 | | MW: | 172.57 | | EINECS: | | | Product Categories: | | | Mol File: | 1018678-38-0.mol |  |
| | 4-amino-2-chloronicotinic acid Chemical Properties |
| Boiling point | 419.4±45.0 °C(Predicted) | | density | 1.577±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 1.21±0.25(Predicted) | | Appearance | White to yellow Solid |
| | 4-amino-2-chloronicotinic acid Usage And Synthesis |
| Synthesis | Preparation of 4-amino-2-chloronicotinic acid: 4-amino-2-chloronicotinic acid methyl ester (21.0 g, 112.9 mmol) and LiOH (10.3 g, 247.5 mmol) were added to a solvent mixture of dioxane:MeOH:water (3:2:1). The reaction mixture was heated to 85 °C and kept for 2 hours. The solvent was removed by evaporation under reduced pressure and the residue was dissolved in a minimum volume of water and acidified to pH 4 with saturated citric acid solution. the aqueous solution was concentrated until a precipitate just started to appear. The mixture was allowed to stand overnight at 10°C to allow complete precipitation. The resulting white solid was collected by filtration and recrystallized from the mixture of isopropanol-hexane solvent to give 4-amino-2-chloronicotinic acid (13 g, 66% yield).1H NMR (400 MHz, DMSO-d6): δ 7.59 (d, 1H), 6.47 (d, 1H), 6.37 (brs, 2H). | | References | [1] Patent: US2008/85887, 2008, A1. Location in patent: Page/Page column 18 |
| | 4-amino-2-chloronicotinic acid Preparation Products And Raw materials |
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