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| | 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline Basic information | | Appearance |
| | 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline Chemical Properties |
| Boiling point | 458.9±45.0 °C(Predicted) | | density | 1.489±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 8.17±0.40(Predicted) |
| | 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline Usage And Synthesis |
| Appearance | 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline is a light yellow to yellow powder or crystals. | | Uses | Applications 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol is a useful research chemical,it can be used as pharmaceutical intermediates. | | Synthesis | 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate (200 mg) was used as starting material and dissolved in methanol (2 ml). Subsequently, aqueous ammonia solution (7N, 1 ml) was added to the reaction system. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to afford the target product 4-((3-chloro-2-fluorophenyl)amino)-7-methoxy-6-ol (white solid, 176 mg, quantitative yield). | | References | [1] Patent: CN108329276, 2018, A. Location in patent: Paragraph 0075; 0076
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 18, p. 4455 - 4459
[3] Patent: WO2005/28469, 2005, A1. Location in patent: Page/Page column 59
[4] Patent: WO2005/28470, 2005, A1. Location in patent: Page/Page column 54
[5] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 18, p. 4908 - 4912 |
| | 4-(3-Chloro-2-fluoroanilino)-6-hydroxy-7- methoxyquinazoline Preparation Products And Raw materials |
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