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| | NSC 98778 Basic information |
| Product Name: | NSC 98778 | | Synonyms: | 5'-Azido-5'-deoxyadenosine;5'-Azidoadenosine;5'-Deoxy-5'-azidoadenosine;NSC 98778;5’-Azido-5’-deoxyadenosine;(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(azidomethyl)tetrahydrofuran-3,4-diol | | CAS: | 737-76-8 | | MF: | C10H12N8O3 | | MW: | 292.25408 | | EINECS: | | | Product Categories: | | | Mol File: | 737-76-8.mol |  |
| | NSC 98778 Chemical Properties |
| | NSC 98778 Usage And Synthesis |
| Uses | 5′-Azido-5′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5′-Azido-5′-deoxyadenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | References | [1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
| | NSC 98778 Preparation Products And Raw materials |
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