L-Leucyl-L-Leucine methyl ester (hydrochloride)
| 中文名稱 | L-Leucyl-L-Leucine methyl ester (hydrochloride) |
|---|---|
| 中文同義詞 | (S)-2-((S)-2-氨基-4-甲基戊酰胺基)-4-甲基戊酸甲酯鹽酸鹽;化合物LEU-LEU-OME HYDROCHLORIDE;化合物LEU-LEU-OME HYDROCHLORIDE,10 MM DMSO 溶液;L-Leucyl-L-Leucine methyl ester hydrochloride #天然產(chǎn)物 HY-129905;L-Leucyl-L-Leucine methyl ester hydrochloride #天然產(chǎn)物 HY-129905 |
| 英文名稱 | L-Leucyl-L-Leucine methyl ester (hydrochloride) |
| 英文同義詞 | L-Leucyl-L-Leucine methyl ester (hydrochloride);methyl (2S)-2-[(2S)-2-amino-4-methylpentanamido]-4-methylpentanoate hydrochloride;Leu-Leu-ome hydrochloride;L-Leucine, L-leucyl-, methyl ester, monohydrochloride;lymphocytes,leukocytes,monocytes,pathway,LLeucylLLeucine methyl ester hydrochloride,LLOMe,inhibit,polymorphonuclear,stress,Leu-Leu methyl ester,cytotoxic,Inhibitor,L Leucyl L Leucine methyl ester hydrochloride,Endogenous Metabolite,endolysosomal;L-Leucyl-L-Leucine methyl ester hydrochloride, 10 mM in DMSO;H-Leu-leu-OMe hydrochloride;L-Leucyl-L-Leucine methyl ester |
| CAS號 | 6491-83-4 |
| 分子式 | C13H27ClN2O3 |
| 分子量 | 294.81808 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 6491-83-4.mol |
| 結構式 |  |
L-Leucyl-L-Leucine methyl ester (hydrochloride) 性質(zhì)
| 熔點 | 177-181°C |
|---|---|
| 儲存條件 | Hygroscopic, Refrigerator, under inert atmosphere |
| 溶解度 | DMSO（少許）、水（少許） |
| 形態(tài) | 固體 |
| 顏色 | 白色至類白色 |
| 穩(wěn)定性 | 吸濕性 |
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride 是人單核細胞或多形核白細胞產(chǎn)生的 L-亮氨酸甲酯的二肽縮合產(chǎn)物，可選擇性消除具有細胞毒性潛能的淋巴細胞。L-Leucyl-L-Leucine methyl ester hydrochloride 也可以誘導溶酶體途徑應激。
L-Leucyl-L-Leucine methyl ester (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells.
L-Leucyl-L-Leucine methyl ester (10-250 μM; 15 min) is converted to a CCI
3
COOH-insoluble product by CD4
-
lymphocytes.