R-IMPP

R-IMPP Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:R-IMPP
CAS:2133832-83-2
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:R-IMPP
CAS:2133832-83-2
Purity:99.7% Package:2mg;32USD|5mg;49USD|10mg;88USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:R-IMPP
CAS:2133832-83-2
Purity:98% Package:1mg Remarks:V6648
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:R-IMPP
CAS:2133832-83-2
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +86-18621343501; +undefined18621343501
Email: product@acmec-e.com
Products Intro: Product Name:R-IMPP
CAS:2133832-83-2
Purity:99% Package:25mg, 10mg, 5mg, 50mg

R-IMPP manufacturers

  • R-IMPP
  • R-IMPP pictures
  • $54.00
  • 2026-06-02
  • CAS:2133832-83-2
  • Purity: 99.85%
  • Supply Ability: 10g
R-IMPP Basic information
Product Name:R-IMPP
Synonyms:R-IMPP;Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl-;PF-00932239 (R-IMPP);(R)-N-(Isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide;Serine endopeptidases,PF-00932239,PF 00932239,inhibit,Ser/Thr Protease,RIMPP,R-IMPP,Inhibitor,Threonine proteases,R IMPP,PF00932239,Serine proteases;R-IMPP, 10 mM in DMSO
CAS:2133832-83-2
MF:C24H27N3O2
MW:389.49
EINECS:
Product Categories:
Mol File:2133832-83-2.mol
R-IMPP Structure
R-IMPP Chemical Properties
Boiling point 594.4±50.0 °C(Predicted)
density 1.186±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 1 mg/ml; DMSO: 10 mg/ml
form A crystalline solid
pka9.14±0.10(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
R-IMPP Usage And Synthesis
Description(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 μM). It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels. (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation.
UsesR-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation[1].
References[1] Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371 DOI:10.1016/j.chembiol.2016.08.016
R-IMPP Preparation Products And Raw materials
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