- Cbz-L-Tle-OH
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2026-07-30
- CAS:62965-10-0
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T
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| | Cbz-L-tert-Leucine Basic information |
| | Cbz-L-tert-Leucine Chemical Properties |
| Boiling point | 436.4±38.0 °C(Predicted) | | density | 1.160±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | form | Oil | | pka | 4.01±0.10(Predicted) | | color | Pale to Light Yellow | | Optical Rotation | Consistent with structure | | CAS DataBase Reference | 62965-10-0 |
| HazardClass | IRRITANT | | HS Code | 29225090 |
| | Cbz-L-tert-Leucine Usage And Synthesis |
| Chemical Properties | Pale Yellow Thick Oil | | Uses | Cbz-L-tert-Leucine is a leucine derivative used in the preparation of various pharmaceutical agents such as TRPV4 antagonists, HIV-1 protease inhibitors and serine protease inhibitors. | | Synthesis | Step A: Synthesis of (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid; to a methanolic (200 mL) suspension of L-tert-leucine (11.88 g, 90.7 mmol) was sequentially added triethylamine (26.56 mL, 190 mmol) and N-(benzyloxycarbonyloxy)succinimide (24.88 g, 99.8 mmol). The reaction mixture was stirred at room temperature for 14 hours. After completion of the reaction, methanol was removed by rotary evaporator under reduced pressure to give a viscous light yellow oil. The oily substance was dissolved in ethyl acetate (100 mL) and the organic layer was washed sequentially with 1 M hydrochloric acid (15 mL) and saturated saline. The organic layer was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure by rotary evaporator to afford the title compound (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid as an oil (24 g, quantitative yield).1H-NMR (CDCl3) δ: 7.43-7.36 (5H, m), 5.36 (1H, d, J = 9.4 Hz) , 5.12 (2H, br s), 4.20 (1H, d, J = 9.6 Hz), 1.02 (9H, s).LRMS: m/z 266 [M + H]+, 264 [M - H]-, 529 [2M - H]-. | | References | [1] Patent: EP1210330, 2005, B1. Location in patent: Page/Page column 9-10 |
| | Cbz-L-tert-Leucine Preparation Products And Raw materials |
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