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| | 4-Amino-2,6-difluorophenol Basic information |
| | 4-Amino-2,6-difluorophenol Chemical Properties |
| Melting point | 0°C | | Boiling point | 0°C | | density | 1.472±0.06 g/cm3(Predicted) | | Fp | 0°C | | storage temp. | Sealed in dry,Room Temperature | | pka | 7.72±0.23(Predicted) | | form | solid | | color | Brown | | CAS DataBase Reference | 126058-97-7 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | HS Code | 2908990000 |
| | 4-Amino-2,6-difluorophenol Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 4-amino-2,6-difluorophenol from 2-(benzyloxy)-1,3-difluoro-5-nitrobenzene: To a solution of 2-(benzyloxy)-1,3-difluoro-5-nitrobenzene (5.3 g, 20 mmol) in ethanol (100 mL) was added 10% palladium/activated carbon (1.5 g). The reaction mixture was stirred overnight at room temperature and 1 atmosphere of hydrogen at 1 atm. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 4-amino-2,6-difluorophenol (2.9 g, 95% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.68 (br s, 1H), 6.19 (d, J = 10.8 Hz, 2H), 5.01 (s, 2H). | | References | [1] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 68 |
| | 4-Amino-2,6-difluorophenol Preparation Products And Raw materials |
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