2',4'-Dihydroxy-2-phenylacetophenone manufacturers
|
| | 2',4'-Dihydroxy-2-phenylacetophenone Basic information |
| | 2',4'-Dihydroxy-2-phenylacetophenone Chemical Properties |
| Melting point | 112-116 °C(lit.) | | Boiling point | 225°C/10mmHg(lit.) | | density | 1.278±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 7.74±0.35(Predicted) | | color | White to Light yellow to Light orange | | InChI | 1S/C14H12O3/c15-11-6-7-12(14(17)9-11)13(16)8-10-4-2-1-3-5-10/h1-7,9,15,17H,8H2 | | InChIKey | VFQKAJVKZKHVPD-UHFFFAOYSA-N | | SMILES | Oc1ccc(c(O)c1)C(=O)Cc2ccccc2 | | CAS DataBase Reference | 3669-41-8(CAS DataBase Reference) | | NIST Chemistry Reference | 2,4-Dihydroxyphenylbenzyl ketone(3669-41-8) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | HS Code | 29145000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2',4'-Dihydroxy-2-phenylacetophenone Usage And Synthesis |
| Chemical Properties | off-white crystalline powder | | Uses | 1-(2,4-Dihydroxyphenyl)-2-phenylethanone is used in preparation of substituted pyrazoles, pyrimidines, triazoles and related heterocycles as c-MYC targeting agents for treatment of cancer and other proliferative diseases. | | Preparation | Preparation by Friedel–Crafts acylation of resorcinol with phenylacetyl chloride in the presence of aluminium chloride,
in methylene chloride (85%) ;
in nitrobenzene at 70–80° for 15 min (<80%), at r.t. for 24 h (63%) or for 2 days (60%);
in ethyl ether at r.t. for 24 h (43%). |
| | 2',4'-Dihydroxy-2-phenylacetophenone Preparation Products And Raw materials |
|