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| | 6-CHLORO-7-METHYLPURINE Basic information |
| | 6-CHLORO-7-METHYLPURINE Chemical Properties |
| Melting point | 175-185°C | | Boiling point | 321.7±45.0 °C(Predicted) | | density | 1.59±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly) | | form | Solid | | pka | 0.65±0.30(Predicted) | | color | Light Green to Grey-Blue | | CAS DataBase Reference | 5440-17-5 |
| | 6-CHLORO-7-METHYLPURINE Usage And Synthesis |
| Chemical Properties | Light Green Solid | | Uses | 6-CHLORO-7-METHYLPURINE is a useful synthetic intermediate. | | Synthesis | To a 1L three-necked round-bottomed flask was added 6-chloro-9H-purine (15.4 g, 0.1 mol, 1 eq.) and tetrahydrofuran (155 mL) at 0 °C and protected by nitrogen in an inert atmosphere. Methylmagnesium chloride (MeMgCl, 36.6 mL, 1.0 M THF solution, 1.1 eq.) was added dropwise with stirring. The reaction mixture was continued to be stirred at 0 °C for 30 min. Subsequently, iodomethane (42.6 g, 3 eq.) was added slowly and dropwise with stirring. The resulting reaction solution was transferred to a 50 °C oil bath and the reaction was stirred for 5 hours. Upon completion of the reaction, the reaction was quenched by addition of 50 mL of aqueous ammonium chloride (NH4Cl) and extracted with dichloromethane (3 x 50 mL). The organic layers were combined and washed with brine (2 x 50 mL) and subsequently concentrated under vacuum. The crude product was recrystallized by dichloromethane/petroleum ether (1:10) to afford 6-chloro-7-methylpurine as a light green solid (7 g, 42% yield). | | References | [1] Organic Letters, 2016, vol. 18, # 1, p. 16 - 19
[2] Patent: WO2018/96159, 2018, A1. Location in patent: Paragraph 0169-0172 |
| | 6-CHLORO-7-METHYLPURINE Preparation Products And Raw materials |
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