- AMAROGENTIN
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2026-07-23
- CAS:21018-84-8
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 1000kg
- AMAROGENTIN
-
-
2026-06-30
- CAS:21018-84-8
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
- AMAROGENTIN
-
- $33.00
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2026-05-11
- CAS:21018-84-8
- Purity: 99.98%
- Supply Ability: 10g
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| | AMAROGENTIN Basic information |
| Product Name: | AMAROGENTIN | | Synonyms: | (4aS)-6α-[2-O-[(3,3',5-Trihydroxy-1,1'-biphenyl-2-yl)carbonyl]-β-D-glucopyranosyloxy]-5β-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one;Amarogentin Hydrate;AMAROGENTIN;Amarogentin from Gentia lutea;Amarogentin, 98%, from Gentiana scabra Bunge;1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-4,4a,5,6-tetrahydro-6-[[2-O-[(3,3',5-trihydroxy[1,1'-biphenyl]-2-yl)carbonyl]-β-D-glucopyranosyl]oxy]-, (4aS,5R,6S)-;(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-2-(((3S,4R,4aS)-8-oxo-4-vinyl-3,4,4a,5,6,8-hexahydropyrano[3,4-c]pyran-3-yl)oxy)tetrahydro-2H-pyran-3-yl 3,3',5-trihydroxy-[1,1'-biphenyl]-2-carboxylate;Amarogentin-RM | | CAS: | 21018-84-8 | | MF: | C29H30O13 | | MW: | 586.54 | | EINECS: | | | Product Categories: | | | Mol File: | 21018-84-8.mol |  |
| | AMAROGENTIN Chemical Properties |
| Melting point | 229-230° (monohydrate) | | alpha | D20 -116.6° (methanol) | | Boiling point | 928.5±65.0 °C(Predicted) | | density | 1.59±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 1 mg/ml; DMSO: 2 mg/ml; PBS (pH 7.2): 0.1 mg/ml | | form | A crystalline solid | | pka | 7.42±0.40(Predicted) | | color | White to off-white | | Major Application | food and beverages | | InChIKey | FWSMZQZCMSGCCU-WKYWRJDANA-N | | SMILES | [C@@]12([H])CCOC(=O)C1=CO[C@@H](OC[C@@H]1[C@@H](O)[C@@H]([C@@H](O)[C@H](OC(=O)C3=CC(=C(C4C=CC=C(O)C=4)C(O)=C3)O)O1)O)[C@@H]2C=C |&1:0,10,13,14,16,17,19,40,r| | | LogP | 2.503 (est) |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | AMAROGENTIN Usage And Synthesis |
| Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the dry roots and rhizomes of Gentiana Gentiana scabra Bge. | | Uses | Amarogentin has the functions of protecting liver and gallbladder, inhibiting bacteria and diuretic. | | Definition | ChEBI: Amarogentin is a secoiridoid glycoside that consists of (4aS,5R,6R)-5-ethenyl-6-hydroxy-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one having a 2-O-[(3,3',5-trihydroxybiphenyl-2-yl)carbonyl]-beta-D-glucopyranosyl group attached at position 6 via a glycosidic linkage. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor and a metabolite. It is a secoiridoid glycoside and a monosaccharide derivative. | | in vivo | Amarogentin (100 mg/kg, p.o.) relieves Carbon tetrachloride (HY-Y0298)-induced liver fibrosis, decreases α-SMA and TGF-β1 expression in mice[1].
| Animal Model: | Carbon tetrachloride (HY-Y0298)-induced liver fibrosis mice model[1] | | Dosage: | 100 mg/kg | | Administration: | p.o. | | Result: | Decreased hepatic α-SMA and TGF-β1 expression.
Inhibited phosphorylation of JNK, ERK, and p38. |
| | target | | Target | Value | TAS2R1
() | TNF-α
() | AMPK
() |
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| | AMAROGENTIN Preparation Products And Raw materials |
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