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Creative Peptides
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| Products Intro: |
Product Name:Phrixotoxin 3
CAS:880886-00-0
Purity:>98% Package:1g; 10g;100g;1kg Remarks:Peptide Inhibitors
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| | PHRIXOTOXIN 3 Basic information |
| | PHRIXOTOXIN 3 Chemical Properties |
| storage temp. | Store at -20°C | | form | Powder | | Water Solubility | Soluble to 1 mg/ml in water |
| | PHRIXOTOXIN 3 Usage And Synthesis |
| Description | Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV2, NaV3 and NaV5 respectively). Blocks inward sodium currents in a voltage-dependent manner. | | Uses | Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current[1]. | | IC 50 | Nav1.3: 42 nM (IC50); Nav1.4: 72 nM (IC50); Nav1.5: 610 nM (IC50); Nav1.2: 0.6 nM (IC50); Nav1.1: 288 nM (IC50) | | storage | Store at -20°C | | References | [1] Bosmans F, et, al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Comparative Study Mol Pharmacol. 2006 Feb; 69(2): 419-29. DOI:10.1124/mol.105.015941 |
| | PHRIXOTOXIN 3 Preparation Products And Raw materials |
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