170365-25-0
| 中文名稱(chēng) | 170365-25-0 |
|---|---|
| 中文同義詞 | 化合物 T11792;化合物 KW-8232 FREE BASE;KW-8232 free base試劑;KW-8232 free base試劑 |
| 英文名稱(chēng) | KW-8232 free base |
| 英文同義詞 | KW-8232 free base;Methanone, [3-[bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl][4-(2-chlorophenyl)-1-piperazinyl]-;KW8232 free base,KW 8232 free base |
| CAS號(hào) | 170365-25-0 |
| 分子式 | C36H37ClN4O3 |
| 分子量 | 609.16 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 170365-25-0.mol |
| 結(jié)構(gòu)式 |  |
170365-25-0 性質(zhì)
| 沸點(diǎn) | 805.5±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 9.95±0.10(Predicted) |
| 顏色 | 米白色至粉紅色 |
KW-8232 free base 是一種抗骨質(zhì)疏松劑，可以減少前列腺素 PGE2 的生物合成。
Prostaglandin Receptor
KW-8232 free base is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE 2 in mouse osteoblastic cells.
KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100304 | 170365-25-0 KW-8232 free base | 170365-25-0 | 1mg | 8500元 |