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BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
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Product Name:MRS 5698
CAS:1377273-00-1
Purity:>=96% by HPLC Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:MRS 5698
CAS:1377273-00-1
Purity:>98% Package:1mg;10mg;50mg;100mg;
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(1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide manufacturers
- MRS5698
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2025-12-22
- CAS:1377273-00-1
- Purity:
- Supply Ability: 10g
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| | (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Basic information |
| Product Name: | (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide | | Synonyms: | (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide;MRS 5698;Bicyclo[3.1.0]hexane-1-carboxamide, 4-[6-[[(3-chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methyl-, (1S,2R,3S,4R,5S)- | | CAS: | 1377273-00-1 | | MF: | C28H23ClF2N6O3 | | MW: | 564.97 | | EINECS: | | | Product Categories: | | | Mol File: | 1377273-00-1.mol | ![(1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Structure](CAS/20200331/GIF/1377273-00-1.gif) |
| | (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Chemical Properties |
| density | 1.58±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 13.31±0.70(Predicted) |
| | (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Usage And Synthesis |
| Uses | MRS 5698, is a selective A3 adenosine receptor agonist, that reverses mechanoallodynia in several neuropathic pain models in vivo, and it’s orally bioavailable. | | in vivo | MRS5698 (3 nmol/day; intrathecal injection for 25 days) prevents Oxaliplatin-induced mechano-allodynia and hyperalgesia, and attenuates Oxaliplatin-induced NLRP3/IL-1β neuroinflammation[2].
MRS5698 (1 mg/kg; i.p. at days 2, 3 ) reduces the IL-23 induced (IL23 injected in day 0, 1, 3) ear thickness of C57BL/6N mouse during the third and fourth experimental days[3]. | Animal Model: | Oxaliplatin-induced Male Sprague Dawley rats (200–250 g starting weight)[2] | | Dosage: | 3 nmol/day | | Administration: | Intrathecal injection for 25 days | | Result: | Increased the value of mechanical paw withdrawal threshold in grams (PWT) in rat.
Attenuated oxaliplatin-induced expression of NLRP3 and maturation of caspase 1 in the DH-SC.
Reduced IL-1β levels in the spinal cord.
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| | IC 50 | Adenosine A3 receptor: ~3 nM (Ki) | | storage | Store at -20°C |
| | (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide Preparation Products And Raw materials |
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