AZ7550 hydrochloride
| 中文名稱 | AZ7550 hydrochloride |
|---|---|
| 中文同義詞 | 化合物AZ7550 HYDROCHLORIDE;奧斯替尼雜質(zhì)26 鹽酸鹽 |
| 英文名稱 | AZ7550 hydrochloride |
| 英文同義詞 | AZ7550 hydrochloride;EGFR,ErbB-1,Epidermal growth factor receptor,HER1,Drug Metabolite,AZ7550 hydrochloride,inhibit,AZ7550,AZ-7550,AZ 7550,Inhibitor,IGF-1R,AZ-7550 hydrochloride;RMA-291 |
| CAS號(hào) | 2309762-40-9 |
| 分子式 | C??H??ClN?O? |
| 分子量 | 522.05 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 2309762-40-9.mol |
| 結(jié)構(gòu)式 |  |
AZ7550 hydrochloride 性質(zhì)
| 儲(chǔ)存條件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亞砜：1.88 mg/mL（3.60 mM） |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
IC50: 1.6 μM (IGF1R), 88 nM (MLK1), 156 nM (ACK1), 195 nM (ErbB4), 228 nM (MNK2), 302 nM (FLT3), 420 nM (ALK ), 449 nM (FES), 840 nM (IRR), 843 nM (BRK), 977 nM (BLK), 995 nM (FAK), 1256 nM (Ins R), 1317 nM (TEC), 1784 nM (FLT4), 2288 nM (PYK2), 2443 nM (Txk), 5104 nM (BTK)
AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC 50 s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI 50 s of 19, 15, and 537 nM, respectively.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-B0794A | AZ7550 hydrochloride AZ7550 hydrochloride | 2309762-40-9 | 5mg | 2800元 |
| 2026/06/05 | HY-B0794A | AZ7550 hydrochloride AZ7550 hydrochloride | 2309762-40-9 | 10mg | 4400元 |