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| | Ethyl 2-oxocyclopentanecarboxylate Basic information |
| Product Name: | Ethyl 2-oxocyclopentanecarboxylate | | Synonyms: | ETHYL-2-CYCLOPENTANONECARBOXYLATE;ETHYL 2-OXOCYCLOPENTANECARBOXYLATE;CYCLOPENTANONE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl 2-oxocyclopentanecarboxylate, tech., 90% 100GR;Ethyl 2-oxocyclopentanecarboxylate, tech., 90% 25GR;2-Carbethoxycyclopentanone
2-Ethoxycarbonylcyclopentanone
Cyclopentanone-2-carboxylic Acid Ethyl Ester
Ethyl Cyclopentanone-2-carboxylate
2-Oxocyclopentanecarboxylic Acid Ethyl Ester;Ethyl 2-oxocyclopentanecarboxylate,2-(Ethoxycarbonyl)cyclopentanone, Ethyl cyclopentanone-2-carboxylate;Ethyl-2-cyclopentanonecarboxylate 10g [611-10-9] | | CAS: | 611-10-9 | | MF: | C8H12O3 | | MW: | 156.18 | | EINECS: | 210-253-0 | | Product Categories: | Pharmaceutical Intermediates;BUILDING BLOCKS;C8 to C9;Carbonyl Compounds;Chemical Synthesis;Esters;fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis;fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis, functional materials;Organic Building Blocks | | Mol File: | 611-10-9.mol |  |
| | Ethyl 2-oxocyclopentanecarboxylate Chemical Properties |
| Boiling point | 102-104 °C/11 mmHg (lit.) | | density | 1.054 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.452(lit.) | | Fp | 172 °F | | storage temp. | Sealed in dry,Room Temperature | | form | Liquid | | pka | 12.02±0.20(Predicted) | | color | Clear colorless to pale yellow | | Water Solubility | insoluble | | BRN | 387787 | | InChI | InChI=1S/C8H12O3/c1-2-11-8(10)6-4-3-5-7(6)9/h6H,2-5H2,1H3 | | InChIKey | JHZPNBKZPAWCJD-UHFFFAOYSA-N | | SMILES | C1(C(OCC)=O)CCCC1=O | | LogP | 0.330 (est) | | CAS DataBase Reference | 611-10-9(CAS DataBase Reference) | | NIST Chemistry Reference | Cyclopentanecarboxylic acid, 2-oxo-, ethyl ester(611-10-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 23-24/25-36/37-26 | | WGK Germany | 3 | | F | 10 | | HazardClass | IRRITANT | | HS Code | 29183000 | | Storage Class | 10 - Combustible liquids |
| | Ethyl 2-oxocyclopentanecarboxylate Usage And Synthesis |
| Description | Ethyl 2-oxocyclopentanecarboxylate (EOCPC) is a multifunctional organic reagent that can be used as a pharmaceutical intermediate or raw material for chemical synthesis. EOCPC reacts with kaolinite to prepare intercalation compounds. It also participates in Michael reactions and diazonium transfer reactions for the preparation of other active ingredients. | | Chemical Properties | clear colourless to pale yellow liquid | | Uses | Pharmaceutical intermediate. | | Uses | Ethyl 2-oxocyclopentanecarboxylate was used in stereoselective synthesis of (±)-cis,cis-spiro[4.4]nonane-1,6-diol. It was also used in the synthesis of tanikolide. | | Synthesis Reference(s) | Journal of the American Chemical Society, 85, p. 207, 1963 DOI: 10.1021/ja00885a021
The Journal of Organic Chemistry, 55, p. 5037, 1990 DOI: 10.1021/jo00304a014
Tetrahedron Letters, 22, p. 1353, 1981 DOI: 10.1016/S0040-4039(01)90316-8 | | General Description | Phase-transfer benzylation reaction of ethyl 2-oxocyclopentanecarboxylate with benzyl bromide in microreactor has been investigated. Ethyl 2-oxocyclopentanecarboxylate participates in cobalt (II) Schiff′s base complex catalyzed oxidation of primary and secondary alcohols. | | Hazard | Vapors are toxic, as is skin contact. |
| | Ethyl 2-oxocyclopentanecarboxylate Preparation Products And Raw materials |
| Raw materials | Tetrahydrofuran-->Acetic acid-->Sodium-->Toluene-->Potassium tert-butoxide-->Diethyl adipate-->Cyclopentanecarboxylic acid, 1-bromo-2-oxo-, ethyl ester-->1,4-Dioxaspiro[4.4]nonane-6-carboxylic acid, ethyl ester | | Preparation Products | 3-Indolepropionic acid-->1-Cyclopentene-1-carboxylic acid, 2-(benzoylamino)-, ethyl ester-->Naphth[2,3-b]oxiren-2(1aH)-one, 7,7a-dihydro-7-hydroxy-1a,7-dimethyl--->2-CYCLOPENTANONE CARBOXYLATE-->3-oxo-2-pentylcyclopentaneacetic acid-->7-Hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one-->MDL-29951-->Monoethyl Adipate |
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