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| | methyl phenothiazin-10-yl ketone Basic information |
| Product Name: | methyl phenothiazin-10-yl ketone | | Synonyms: | methyl phenothiazin-10-yl ketone;1-(10H-Phenothiazin-10-yl)ethanone;1-phenothiazin-10-ylethanone;10-acetyl-10H-phenothiazine;Ethanone,1-(10H-phenothiazin-10-yl)-;10-ACETYLPHENOTHIAZINE | | CAS: | 1628-29-1 | | MF: | C14H11NOS | | MW: | 241.31 | | EINECS: | 216-621-7 | | Product Categories: | | | Mol File: | 1628-29-1.mol |  |
| | methyl phenothiazin-10-yl ketone Chemical Properties |
| Melting point | 198 °C(Solv: ethanol (64-17-5)) | | Boiling point | 470.6±15.0 °C(Predicted) | | density | 1.284±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to crystal | | pka | -3.65±0.20(Predicted) | | color | White to Light yellow to Light orange | | InChI | InChI=1S/C14H11NOS/c1-10(16)15-11-6-2-4-8-13(11)17-14-9-5-3-7-12(14)15/h2-9H,1H3 | | InChIKey | DNVNQWUERFZASD-UHFFFAOYSA-N | | SMILES | C(=O)(N1C2=CC=CC=C2SC2=C1C=CC=C2)C |
| | methyl phenothiazin-10-yl ketone Usage And Synthesis |
| Uses | 10-Acetylphenothiazine has been studied as a possible redox shuttle additive for chemical overcharge and overdischarge protection for lithium-ion batteries. It was used as a reagent in the synthesis of triazolopyridinylphenothiazines which displayed significant antibacterial and antifungal activity. | | Synthesis | 1. 20 g (0.1 mol) of phenothiazine and 200 mL of toluene are added to a 500 mL flask.
2. 14.3 mL (2 equiv.) of acetyl chloride was added slowly and dropwise to the flask.
3. The reaction mixture was stirred at 50 °C for 1 h to ensure complete reaction.
4. Upon completion of the reaction, the mixture was concentrated to dryness.
5. The resulting precipitate was dissolved in a minimal amount of isopentane followed by filtration.
6. After drying, 24 g of a beige solid product, 1-(10H-phenothiazin-10-yl)ethanone, was obtained in quantitative yield. 7. The product had a melting point of 2.0%.
7. The melting point of the product was 210-211 °C. The product was dried. | | References | [1] Patent: US2005/222045, 2005, A1. Location in patent: Page/Page column 13
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 14, p. 4113 - 4126
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 1, p. 101 - 105
[4] Indian Journal of Heterocyclic Chemistry, 2018, vol. 28, # 2, p. 221 - 226
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004, vol. 43, # 1, p. 157 - 161 |
| | methyl phenothiazin-10-yl ketone Preparation Products And Raw materials |
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