| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:SRI-41315
CAS:1613509-49-1
Package:25mg;5mg Remarks:V37584
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| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:SRI-41315
CAS:1613509-49-1
Purity:大于98% Package:1g,5g,10g,25g根據(jù)客戶需要分裝 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
Aikon International Limited
|
| Tel: |
025-58859352 19370895928 |
| Email: |
dt3@aikonchem.com |
| Products Intro: |
CAS:1613509-49-1
Purity:95% Package:1g;5g;10g
|
Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- manufacturers
- SRI-41315
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2026-05-13
- CAS:1613509-49-1
- Purity:
- Supply Ability: 10g
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| | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Basic information |
| Product Name: | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- | | Synonyms: | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-;SRI-41315;2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione;2-cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5-dione;2-cyclobutyl-10-methyl-3-phenylpyrimidinebenzo[4，5-b]quinoline-4，5(3H，10H)-dione | | CAS: | 1613509-49-1 | | MF: | C22H19N3O2 | | MW: | 357.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1613509-49-1.mol | ![Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Structure](CAS/20210305/GIF/1613509-49-1.gif) |
| | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Chemical Properties |
| Boiling point | 495.3±55.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | -10 to -25°C | | solubility | DMSO: 2mg/mL, clear (Warmed) | | form | Solid | | pka | 2.41±0.20(Predicted) | | color | Light yellow to yellow | | SMILES | O=C1N(C2=CC=CC=C2)C(C3CCC3)=NC4=C1C(C5=CC=CC=C5N4C)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Usage And Synthesis |
| Description | SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. SRI-41315 induce a prolonged pause at stop codons and suppress PTCs associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity. | | Uses | SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity[1]. | | References | [1] Sharma J, et al. A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. Nat Commun. 2021 Jul 16;12(1):4358. DOI:10.1038/s41467-021-24575-x |
| | Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl- Preparation Products And Raw materials |
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