218137-86-1
| 中文名稱(chēng) | 218137-86-1 |
|---|---|
| 中文同義詞 | 化合物 T10657;化合物C75;化合物C75,10 MM DMSO 溶液;C75 抑制劑;C75(218137-86-1);C75 抑制劑;4-亞甲基-2-辛基-5-氧代四氫呋喃-3-羧酸;3-羧基-4-辛基-2-亞甲基丁內(nèi)酯 |
| 英文名稱(chēng) | 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE |
| 英文同義詞 | 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE;C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid);TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE;TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID;FAS inhibitor C75 (C-75;3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-;C75 >=98% (HPLC), powder;C75, 10 mM in DMSO |
| CAS號(hào) | 218137-86-1 |
| 分子式 | C14H22O4 |
| 分子量 | 254.32 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 218137-86-1.mol |
| 結(jié)構(gòu)式 | ![]() |
218137-86-1 性質(zhì)
| 沸點(diǎn) | 432.1±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.08±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 二甲基亞砜:18 毫克/毫升 |
| 酸度系數(shù)(pKa) | 3.08±0.40(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 米白色 |
| InChI | 1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16) |
| InChIKey | VCWLZDVWHQVAJU-UHFFFAOYSA-N |
| SMILES | CCCCCCCCC1OC(=O)C(=C)C1C(O)=O |
IC50: 35 μM (PC3 cell)
C75 inhibits PC3 cell growht with an IC 50 of 35 μM at 24 h. C75 (10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC 50 of 50 μM. (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity.
C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA.
安全信息
| WGK Germany | 3 |
|---|---|
| 存儲(chǔ)類(lèi)別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-12364R | 218137-86-1 C75 (Standard) | 218137-86-1 | 1 mg | 1200元 |
| 2026/06/05 | HY-12364R | 218137-86-1 C75 (Standard) | 218137-86-1 | 5 mg | 3000元 |
