- Pipequaline
-
- $1.00
-
2019-12-26
- CAS:77472-98-1
- Min. Order: 1KG
- Purity: 97%-99.9%
- Supply Ability: 100kg
|
| | Pipequaline Basic information |
| Product Name: | Pipequaline | | Synonyms: | Pipequaline;2-Phenyl-4-[2-(4-piperidinyl)ethyl]quinoline;45319RP;PK-8165;RP-45319;pipequaline PK-8165;PK-8165; PK8165; PK 8165;2-phenyl-4-(2-piperidin-4-ylethyl)quinoline | | CAS: | 77472-98-1 | | MF: | C22H24N2 | | MW: | 316.44 | | EINECS: | | | Product Categories: | | | Mol File: | 77472-98-1.mol |  |
| | Pipequaline Chemical Properties |
| Boiling point | 489.2±30.0 °C(Predicted) | | density | 1.078±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml | | form | A crystalline solid | | pka | 10.60±0.10(Predicted) | | color | White to off-white |
| | Pipequaline Usage And Synthesis |
| Description | Pipequaline is a partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay). In mice, pipequaline enhances the effects of diazepam , further reducing foot shock-induced fighting behavior and the number of maximal electroshock-induced seizures and potentiating the muscle relaxant and hypnotic effects. Pipequaline also increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity that can be reversed by the benzodiazepine receptor antagonist flumazenil . | | Uses | Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity[1][2]. | | in vivo | Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3]. | | References | [1] Bradwejn J, et al. Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-inducedactivation of hippocampal pyramidal neurons: a microiontophoretic study in the rat. Eur J Pharmacol. 1985 Jun 19;112(3):415-8. DOI:10.1016/0014-2999(85)90790-3
[2] Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42. DOI:10.1016/0028-3908(87)90096-7 |
| | Pipequaline Preparation Products And Raw materials |
|