norathyriol manufacturers
- Norathyriol
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- $152.00
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2026-06-02
- CAS:3542-72-1
- Purity: 99.55%
- Supply Ability: 10g
- norathyriol
-
-
2026-02-02
- CAS:3542-72-1
- Min. Order: 5mg
- Purity: 99%HPLC
- Supply Ability: 2000tons
- Norathyriol
-
- $1.00
-
2024-07-20
- CAS:3542-72-1
- Min. Order: 1Kg
- Purity: 98%
- Supply Ability: 20T
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| | norathyriol Basic information |
| Product Name: | norathyriol | | Synonyms: | norathyriol;1,3,6,7-Tetrahydroxy-9H-xanthen-9-one;rathyriol;9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-;Norathyriol, 10 mM in DMSO;1,3,6,7-Tetrahydroxyxanthone;Mangiferitin | | CAS: | 3542-72-1 | | MF: | C13H8O6 | | MW: | 260.2 | | EINECS: | | | Product Categories: | | | Mol File: | 3542-72-1.mol |  |
| | norathyriol Chemical Properties |
| Melting point | 320 °C | | Boiling point | 595.1±50.0 °C(Predicted) | | density | 1.766±0.06 g/cm3(Predicted) | | solubility | DMSO : 100 mg/mL (384.32 mM; Need ultrasonic) | | form | Solid | | pka | 6.68±0.20(Predicted) | | color | White to off-white | | InChI | InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H | | InChIKey | ZHTQCPCDXKMMLU-UHFFFAOYSA-N | | SMILES | C1(=O)C2=C(C=C(O)C(O)=C2)OC2=C1C(O)=CC(O)=C2 |
| | norathyriol Usage And Synthesis |
| Uses | Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 μM, 102.4 μM, and 153.5 μM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities. | | Definition | ChEBI: A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity again
t protein kinase C. | | in vivo | Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1].
Norathyriol (0.92, 1.85 and 3.7mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4]. | Animal Model: | Adult Kunming mice weighing 18-22g[4] | | Dosage: | 0.92, 1.85 and 3.7mg/kg | | Administration: | Administered intragastrically; twice daily for five times | | Result: | The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%. |
| | IC 50 | PPARα: 92.8 μM (IC50); PPARβ: 102.4 μM (IC50); PPARγ: 153.5 μM (IC50) | | References | [1] Zhi-Long Shi, et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015. DOI:10.1155/2017/1206015
[2] Ashley S Wilkinson,et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42. DOI:10.1021/jf800046n
[3] Jixia Li, et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70. DOI:10.1158/0008-5472.CAN-11-2596
[4] Yanfen Niu, et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6. DOI:10.3109/13880209.2015.1120322 |
| | norathyriol Preparation Products And Raw materials |
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