HDL-16

HDL-16 Suppliers list
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Tel: 15865264761
Email: 486064515@qq.com
Products Intro: Product Name:HDL-16
CAS:2373280-36-3
Purity:98% Package:500mg；1g；5g
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:HDL-16
CAS:2373280-36-3
Purity:97.58% Package:1removed
HDL-16 Basic information
Product Name:HDL-16
Synonyms:HDL-16;2-Benzoxazolemethanamine, N-(4-bromophenyl)-
CAS:2373280-36-3
MF:C14H11BrN2O
MW:303.15
EINECS:
Product Categories:
Mol File:2373280-36-3.mol
HDL-16 Structure
HDL-16 Chemical Properties
Boiling point 438.247±30.00 °C(Press: 760.00 Torr)(predicted)
density 1.547±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka2.206±0.50(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
HDL-16 Usage And Synthesis
UsesHDL-16 is a potent P2Y14R antagonist with an IC50of0.3095nM. HDL-16 ameliorates DSS (HY-116282C)-induced colitis through suppressing necroptosis of intestinal epithelium cells (IECs) and protecting mucosal barrier function[1].
in vivo

HDL-16 (10μM or 20μM; 100μL; Rectally administered; daily; 6 days) with high-dose significantly suppresses colitis symptoms and leads to maintained gut barrier integrity in the mice[1].

Animal Model:Male, 7-8-week-old, P2Y14Rfl/fl Vil-cre (P2Y14RIEC), P2Y14Rfl/fl Lyz2-cre and WT mice with C57BL/6J background[1]
Dosage:10μM or 20μM; 100μL
Administration:Rectally administered; daily; 6 days
Result:With high-dose showed dramatically less body weight loss and lower Disease Activity Index (DAI) than Dextran sodium sulfate (DSS; 36-50kDa; 3% w/v; drinking water for 7 days)-exposed mice.
With high-dose improved DSS-induced inflammatory infiltration and tissue damage.
With high-dose resulted in a prominently suppression in necroptosis of the IECs in DSS-treated mice.
IC 50P2Y14 Receptor: 0.3095 nM (IC50)
References[1] Chunxiao Liu, et al. Targeting P2Y14R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitis. Nat Commun. 2024 Mar 7;15(1):2083. DOI:10.1038/s41467-024-46365-x
HDL-16 Preparation Products And Raw materials
Tag:HDL-16(2373280-36-3) Related Product Information
2-[(dimethylamino)methyl]-1,3-benzoxazol-5-amine (5-bromo-1,3-benzoxazol-2-yl)methanamine hydrochloride HDL-16 N,2-dimethylbenzo[d]oxazol-6-amine 6-Bromobenzoxazole-2-methanamine 5-Aminobenzoxazole-2-methanamine