CSF1R-IN-15

CSF1R-IN-15 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:CSF1R-IN-15
CAS:2925744-43-8
Package:50mg/RMB 13800
CSF1R-IN-15 Basic information
Product Name:CSF1R-IN-15
Synonyms:CSF1R-IN-15;Benzenemethanol, 4-[4-[methyl[(3-methylphenyl)methyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-
CAS:2925744-43-8
MF:C22H22N4O
MW:358.44
EINECS:
Product Categories:
Mol File:2925744-43-8.mol
CSF1R-IN-15 Structure
CSF1R-IN-15 Chemical Properties
density 1.269±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka12.935±0.50(predicted)
Safety Information
MSDS Information
CSF1R-IN-15 Usage And Synthesis
UsesCSF1R-IN-15 (compound 23) is an inhibitor targeting CSF1R. The colony-stimulating factor-1 receptor (CSF1R) is a tyrosine kinase embedded in the cell membrane of macrophages. The receptor is activated by colony-stimulating factor-1 (CSF-1) and interleukin-34, and signaling via CSF1R is crucial for the differentiation, proliferation, and survival of macrophages[1].
in vivo

In vivo pharmacokinetic indices were derived from cassette dosing studies. The t1/2, C0, AUC0-∞, CLobs, and Vss,obs of CSF1R-IN-15 were 0.5 h, 37 ng/mL, 18 h*ng/mL, 54 L/h/kg, and 32 L/kg in C57BLKS mice[1].
Pharmacokinetic Analysis in CSF1R-IN-15 (compound 23) for a cassette dosing study in C57BLKS mice[1]

t1/2 (h)C0 (ng/mL)AUC0-∞ (h*ng/mL)CLobs (L/h/kg)Vss,obs (L/kg)
0.537185432
Animal Model:In Vivo Pharmacokinetic Study
Dosage:1mg/kg
Administration:Intravenous injection (i.v.) single dosing of drugs (1 mg/kg each) in a 20% DMSO, 80% PEG400 formulation. Blood sampling was done after 10, 30, 60, 120, 240, and 480 min.
Result:In vivo pharmacokinetic indexes were t1/2 (0.5 h), C0 (37 ng/mL), AUC0-∞ (18 h*ng/mL), CLobs (54 L/h/kg), and Vss,obs (32 L/kg), respectively.
References[1] Aarhus TI, et al. Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. J Med Chem. 2023 May 25;66(10):6959-6980. DOI:10.1021/acs.jmedchem.3c00428
CSF1R-IN-15 Preparation Products And Raw materials
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